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SIGNIFICANCE OF Ca & PHOSPHATE IN DIET - Coggle Diagram
SIGNIFICANCE OF Ca & PHOSPHATE IN DIET
SLO1 : Diet sources for Ca & phosphate
CALCIUM
Eg :-
DAIRY PRODUCTS
SARDINES
MILK
BROCOLI
SLO2.1 : Body distribution of Ca
BODY DISTRIBUTION
Ca in BLOOD & ECF
1/2
BOUND TO PROTEINS
CONC OF IONIZED Ca
Basal conc of free Ca w/in cells
BONE CALCIUM
MAJORITY STORE Ca IN BONE
99% -- In mineral phase
1% -- rapidly exchange w/ extracellular Ca
INTRACELLULAR Ca
FREE Ca
MITOCHONDRIA // ER
FUNCTION
INTRACELLULAR SIGNALING
ENZYME ACTIVATION
MUSCLE CONTRACTIONS
LOCATION
INFLUX FR ECF
RELEASE FR CELLULAR STORES
SLO2.2 :Fluxes of Ca & phosphorus
Fluxes controlled by :-
INTESTINE // BONE // KIDNEY
TO MAINTAIN BLOOD Ca LEVEL
LOW LEVEL ...
D/T INSUFFICIENT DIET
INCREASE PARATHYROID HORMONE
CAUSE :-
INCREASE ACTIVITY OF 25-HCC-1-HYDROXYLASE IN KIDNEY
SECRETED FR KIDNEY
STIMULATES BIOACTIVE VIT D
CHANGES IN GENE EXPRESSION
1 more item...
PHOSPHORUS
10% phosphate
inorganic & organic compounds
distribution w/in ICF & ECF
SLO2.1 : Body distribution of Phosphorus
DISTRIBUTION
5% -- INTRACELLULAR
<0.03% -- EXTRACELLULAR
90 % -- SKELETON
90% phosphate
mineral phase of bone
store in SKELETON
PHOSPHORUS METABOLISM
0.9 g : absorb fr diet
0.7 g : secreted fr kidney daily
0.25 g : formation of bone daily
0.2 g : secreted
SLO2.3 : Hormonal control systems of Ca & phosphorus
VIT D
TO INCREASE BLOOD Ca LEVELS
GENERATED ACTIVITY OF PTH W/IN KIDNEY
FACILITATE REABSORPTION OF Ca FR SMALL INTESTINE
ENHANCE FLUXES OF Ca OUT OF BONE
PTH
INCREASE BLOOD [Ca]
MOBILIZE INCREASE Ca & PHOSPHATE FR BONE
AFFECT ON KIDNEY
PRODUCE INCREASE ACTIVATED VIT D IN KIDNEY
TO PREVENT INCREASE IN PHOSPHATE
INCREASE TUBULAR REABSORPTION OF Ca
DECREASES Ca IN URINE
CALCITONIN
TO REDUCE BLOOD Ca LEVELS
HYPERCALCEMIA
RELEASE CALCITONIN BY THYROID GLAND
SUPPRESS RENAL TUBULAR REABSORPTION OF Ca
TO ENHANCE EXCRETION OF Ca INTO URINE
INHIIBIT BONE REABSORPTION
DECREASE FLUXES OF Ca FR BONE INTO BLOOD
SLO3 : Factors controlling absorption of Ca & phosphorus
PTH
FAVOR Ca ABSORPTION
CONTROLS FORMATION OF 1,25-DHCC
EFFECT OF pH IN INTESTINE
ACID GASTRIC JUICE
DISSOLVE Ca SALTS & INORGANIC PHOSPHATES
PRECIPITATION FORMED IN SMALL INTESTINES
GROWTH
HORMONE
INCREASE Ca ABSORPTION
REDUCE ENDOGENOUS Ca EXCRETION
AMOUNT OF DIETARY Ca & PHOSPHORUS & Ca : P RATIO
RATIO IMPORTANT FOR :-
ABSORPTION OF TOTAL [Ca]
PHOSPHORUS IN DIET IS LOW
EFFECT OF PREGNANCY
Low plasma Ca
Release PTH
Increase Ca absorption
decrease Ca excretion via urine
LACTOGEN
INCREASE Ca ABSORPTION & BONE REMODELLING
EFFECT OF OXALATES
FREE OXALATES PRECIPITATE Ca
INFLUENCCE OF FAT
REDUCE Ca FX
MORE FAT
INHIBIT Ca IN GUTS
EFFECT OF PROTEIN & AMINO ACID
INCREASE Ca ABSORPTION
EFFECT OF PREVIOUS Ca INTAKE & INCREASE Ca NEEDED
EFFECT OF CHO
INCREASE Ca ABSORPTION
D/T ACID FORMATION
LACTOSE
FAVORS Ca ABSORPTION & BONE CALCIFICATION
D/T SLOW DIGESTION
VIT D & Ca ABSORPTION
1,25-DHCC active on :-
intestinal mucosa
kidney
bone
INCREASE Ca ABSORPTION
ORAL MANIFESTATIONS
WIDENING OF PERIODONTAL LIGAMENT
SEVERE PERIODONTAL LIGAMENT
LOSS OF LAMINA DURA
TOOTH MOBILITY
DENTIN & ENAMEL HYPOPLASIA
MESIAL SHIFTING
DELAYED TOOTH ERUPTION
PULP CALCIFICATIONS