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Pneumonia, Foreign Microbial Agent, Bacteremia, Microorganisms reach the…
Pneumonia
Multi organ failure
Foreign Microbial Agent
Virus
Bacteria
Fungus
Bacteremia
presence of viable bacteria in bloodstream
Microorganisms reach the alveolar space
macrophage kills the microorganisms that reach the alveolar space
No development of clinical PNA
Sepsis
signs & symptoms
Fever, shivering, or feeling very cold
Shortness of breath
confusion or disorientation
Clammy or sweaty skin
Extreme pain or discomfort
high heart rate
Lungs develop an inflammatory response as a final defense mechanism
Movement of white blood cells, lymphocytes and monocytes from the capillaries into the alveolar space
Decreased alveolar space
microvascular clot forms
Lack of oxygen to vital organs
Microaspiration into lungs
Consolidation formation in alveolar space
release of cytokines from neutrophils and macrophages
Alveolar macrophage is unable to control the growth of the microorganisms
cytokines activate extrinsic coagulation cascade
Hosts immune system fails to ID bacteria due to inherited or acquired immune defects
inhibits fibrinolysis
Excess WBC in alveoli causes sputum production and development of cough
dysfunction of one or more major organ system
Tachypnea to bring in more oxygen
systemic hypotension
disturbed perfusion of microcirculation
tissue toxicity
Bacteria bind to surfactant and plug alveolar space
Bacteria enters the bloodstream
Toxins disrupt barrier between pulmonary and vascular sytem
Global inflammatory response
Bacterial proliferation within blood stream leading to blood stream infection (BSI)