ANTIHYPERTENSIVE DRUGS

DIURETICS

SYMPHATHOPLEGICS

VASODILATORS

RAAS

THIAZIDE DIURETICS

LOOP DIURETICS

ALDOSTERONE-BLOCKING DIURETICS

USES

DRUGS

ADVERSE EFFECTS

MILD HYPERTENSION

CHLORTHALIDONE

HYDROCHLOROTHIAZIDE

INDAPAMIDE

CHLOROTHIAZIDE

METOLAZONE

VENTRICULAR RHYTHM DISTURBANCES

DECREASE IN GLUCOSE TOLERANCE

HYPOCHLOREMIA

HYPONATREMIA

HYPOKALEMIA

VOL DEPLETION

ELECTROLYTE ABNORMALITIES

USES

ADVERSE EFFECTS

DRUGS

CONTRAINDICATION

MODERATE / SEVERE HYPERTENSION

HYPOMAGNESEMIA

HYPOCHLOREMIA

VOL DEPLETION

HYPOCALCEMIA

HYPONATREMIA

HYPOKALEMIA

CANT TOGETHER W/ GLYCOSIDES

CANT TOGETHER W/ AMINOGLYCOSIDE ANTIBIOTICS

CANT TOGETHER W/ ARRYHTHMATIC DRUGS

PROBENIC REDUCE EFFECT OF LD

FUROSEMIDE

BUMETANIDE

LASIX

BUMEX

DRUGS

SPIRONOLACTONE

ACEi

ARBs

DRUGS

USES

ADVERSE EFFECTS

STANDARD CARE FOR MI

HYPERTENSION

ENALAPRIL

LISINOPRIL

CAPTOPRIL

HYPOTENSION

HYPERKALEMIA

COUGH

RENIN-ANGIOTENSIS SYSTEM

KALLIKREIN-KININ SYSTEM

ANGIOTENSINOGEN

ANGIOTENSIN I

By RENIN

ANGIOTENSIN II

By ACE

CAUSE :-

VASOCONSTRICTION

INCREASE BP

ALDOSTERONE SECRETION

INCREASE PVR

INCREASE Na+ & WATER RETENTION

KININOGEN

BRADYKININ

By KALLIKREIN

INACTIVATE FRAGMENTS

By ACE

INCREASE PROSTAGLANDINS SYNTHESIS

VASODILATION

DECREASE PVR

DECREASE BP

USES

DRUGS

ADVERSE EFFECTS

ANGIOEDEMA PT

PT W/ COUGH

IRBESARTAN

CANDESSARTAN

LOSARTAN

DRY COUGH

WORSEN RENAL FX

HYPERKALEMIA

HYPOTENSION

FETAL TOXICITY

ANGIOEDEMA

CA BLOCKER

OLD VASOILATORS

EMERGENCY VASODILATORS

DRUGS

USES

MOA

AMLODIPINE

DILTIAZEM

VERAPAMIL

DIABETES

PERIPHERAL VASCULAR DISEASE

ASTHMA

Bind to L-type Ca channel in heart & smooth muscle

BLOCK INWARD MOVEMENT OF Ca2+

cause :-

RELEASE OF NO

OPENING OF K CHANNEL

ACTIVATE D1 DOPAMINE RECEPTORS

HYPERPOLARIZATION

DRUGS

USES

ADVERSE EFFECTS

EMERGENCY MANAGEMENT IV

VASODILATION & TACHYCARDIA

NITROPRUSIDE

DIAZOXIDE

CYANIDE PRODUCTION

DRUGS

MOA

ADVERSE EFFECTS

HYRALAZINE

MINOXIDIL

TRIGGER ANGINA // MI // CARDIAC FAILURE

INCREASE RENIN RETENTION

WATER RETENTION

DIRECT ACTING ON SMOOTH MUSCLE OF ARTERY & ARTERIOLES >> VEIN

SYM 1

SYM 2

SYM 3

SYM 4

SYM 5

DRUGS

MOA

CLONIDINE

ADVERSE EFFECTS

MONOXIDINE

METHYLDOPA

DIZZINESS

SEDATION

REBOUND HYPERTENSION AFTER WITHDRAWAL

NOT TOGETHER W/ TRICYCLIN ANTIDEPRESSANT

DRY MOUTH

ADVERSE EFFECTS

CAUSES

SEDATION

HEPATITIS

HAEMATOLOGIC TOXICITIES

DRY MOUTH

OEDEMA

Stimulate central inhibitory alpha-adrenergic receptors

lower arterial pressure

FALSE NEUROTRANSMISSION

REDUCE PLASMA RENIN ACTIVITY

METHYLDOPA & CLONIDINE

STIMULATE A2 ADRENORECEPTORS

INHIBIT NE RELEASE

MOXONIDINE & CLONIDINE

ACT ON I1 RECEPTORS IN ROSTRAL VENTROLATERAL MEDULLA

Decrease sympa outflow

dec vasoconstriction // HR // myocardial contractility

Increase parasympa outflow

decrease HR

DRUGS

USES

TERAZOSIN

DOXAZOSIN

PRAZOSIN

EXERT MINIMAL EFFECTS ON CO // GFR

BLOOD FLOW NOT DIMINISHED

REDUCE PVR & BP

USES

DRUGS

TRIMETHAPHAN

HEXAMETHONIUM

SEXUAL DYSFX

PARASYMPA BLOCKAGE

ORTHOSTATIC HYPOTENSION

FX :-

DRUGS

DECREASE CO & PVR

RESERPINE

GUANETHIDINE

Depletes NE stores

Block & decrease release of NE

USES

DRUGS

PROPRANOLOL

METAPROLOL

CARVEDILOL

LABETALOL

ANGINA

ACUTE HEART FAILURE

ASTHMA

REDUCE RENIN RELEASE