ANTIHYPERTENSIVE DRUGS
DIURETICS
SYMPHATHOPLEGICS
VASODILATORS
RAAS
THIAZIDE DIURETICS
LOOP DIURETICS
ALDOSTERONE-BLOCKING DIURETICS
USES
DRUGS
ADVERSE EFFECTS
MILD HYPERTENSION
CHLORTHALIDONE
HYDROCHLOROTHIAZIDE
INDAPAMIDE
CHLOROTHIAZIDE
METOLAZONE
VENTRICULAR RHYTHM DISTURBANCES
DECREASE IN GLUCOSE TOLERANCE
HYPOCHLOREMIA
HYPONATREMIA
HYPOKALEMIA
VOL DEPLETION
ELECTROLYTE ABNORMALITIES
USES
ADVERSE EFFECTS
DRUGS
CONTRAINDICATION
MODERATE / SEVERE HYPERTENSION
HYPOMAGNESEMIA
HYPOCHLOREMIA
VOL DEPLETION
HYPOCALCEMIA
HYPONATREMIA
HYPOKALEMIA
CANT TOGETHER W/ GLYCOSIDES
CANT TOGETHER W/ AMINOGLYCOSIDE ANTIBIOTICS
CANT TOGETHER W/ ARRYHTHMATIC DRUGS
PROBENIC REDUCE EFFECT OF LD
FUROSEMIDE
BUMETANIDE
LASIX
BUMEX
DRUGS
SPIRONOLACTONE
ACEi
ARBs
DRUGS
USES
ADVERSE EFFECTS
STANDARD CARE FOR MI
HYPERTENSION
ENALAPRIL
LISINOPRIL
CAPTOPRIL
HYPOTENSION
HYPERKALEMIA
COUGH
RENIN-ANGIOTENSIS SYSTEM
KALLIKREIN-KININ SYSTEM
ANGIOTENSINOGEN
ANGIOTENSIN I
By RENIN
ANGIOTENSIN II
By ACE
CAUSE :-
VASOCONSTRICTION
INCREASE BP
ALDOSTERONE SECRETION
INCREASE PVR
INCREASE Na+ & WATER RETENTION
KININOGEN
BRADYKININ
By KALLIKREIN
INACTIVATE FRAGMENTS
By ACE
INCREASE PROSTAGLANDINS SYNTHESIS
VASODILATION
DECREASE PVR
DECREASE BP
USES
DRUGS
ADVERSE EFFECTS
ANGIOEDEMA PT
PT W/ COUGH
IRBESARTAN
CANDESSARTAN
LOSARTAN
DRY COUGH
WORSEN RENAL FX
HYPERKALEMIA
HYPOTENSION
FETAL TOXICITY
ANGIOEDEMA
CA BLOCKER
OLD VASOILATORS
EMERGENCY VASODILATORS
DRUGS
USES
MOA
AMLODIPINE
DILTIAZEM
VERAPAMIL
DIABETES
PERIPHERAL VASCULAR DISEASE
ASTHMA
Bind to L-type Ca channel in heart & smooth muscle
BLOCK INWARD MOVEMENT OF Ca2+
cause :-
RELEASE OF NO
OPENING OF K CHANNEL
ACTIVATE D1 DOPAMINE RECEPTORS
HYPERPOLARIZATION
DRUGS
USES
ADVERSE EFFECTS
EMERGENCY MANAGEMENT IV
VASODILATION & TACHYCARDIA
NITROPRUSIDE
DIAZOXIDE
CYANIDE PRODUCTION
DRUGS
MOA
ADVERSE EFFECTS
HYRALAZINE
MINOXIDIL
TRIGGER ANGINA // MI // CARDIAC FAILURE
INCREASE RENIN RETENTION
WATER RETENTION
DIRECT ACTING ON SMOOTH MUSCLE OF ARTERY & ARTERIOLES >> VEIN
SYM 1
SYM 2
SYM 3
SYM 4
SYM 5
DRUGS
MOA
CLONIDINE
ADVERSE EFFECTS
MONOXIDINE
METHYLDOPA
DIZZINESS
SEDATION
REBOUND HYPERTENSION AFTER WITHDRAWAL
NOT TOGETHER W/ TRICYCLIN ANTIDEPRESSANT
DRY MOUTH
ADVERSE EFFECTS
CAUSES
SEDATION
HEPATITIS
HAEMATOLOGIC TOXICITIES
DRY MOUTH
OEDEMA
Stimulate central inhibitory alpha-adrenergic receptors
lower arterial pressure
FALSE NEUROTRANSMISSION
REDUCE PLASMA RENIN ACTIVITY
METHYLDOPA & CLONIDINE
STIMULATE A2 ADRENORECEPTORS
INHIBIT NE RELEASE
MOXONIDINE & CLONIDINE
ACT ON I1 RECEPTORS IN ROSTRAL VENTROLATERAL MEDULLA
Decrease sympa outflow
dec vasoconstriction // HR // myocardial contractility
Increase parasympa outflow
decrease HR
DRUGS
USES
TERAZOSIN
DOXAZOSIN
PRAZOSIN
EXERT MINIMAL EFFECTS ON CO // GFR
BLOOD FLOW NOT DIMINISHED
REDUCE PVR & BP
USES
DRUGS
TRIMETHAPHAN
HEXAMETHONIUM
SEXUAL DYSFX
PARASYMPA BLOCKAGE
ORTHOSTATIC HYPOTENSION
FX :-
DRUGS
DECREASE CO & PVR
RESERPINE
GUANETHIDINE
Depletes NE stores
Block & decrease release of NE
USES
DRUGS
PROPRANOLOL
METAPROLOL
CARVEDILOL
LABETALOL
ANGINA
ACUTE HEART FAILURE
ASTHMA
REDUCE RENIN RELEASE