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dendritic spines - Coggle Diagram
dendritic spines
morphology
stubby
filopodium
mushroom-shaped
thin
cup-shaped
function
EPSP amplifier
spine neck resistance is rather large
normalizer
spines standardize EPSP than shafts
standardize calcium influx
facilitate and standardize NMDA currents
compartmentalization
rather isolated compartment for calcium in spine head
could be important for ca signaling beacause the ca concentration is determined by different mechanism in and out of the spines
contact optimization
spines increase membrane area and thus increase contact area
properties
usually form 1 excitatory synapse while inhibitory synapse is usually on the shaft
90% excitatory synapses terminate on spines
human has about 10^13 spines