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Alzheimer, FLO - Coggle Diagram
Alzheimer
no cure
donepazile
galasatsdmain
rivastaigmins
memansj
just lower signs
phase III ride
deep brain stimulation
genetics
APOE4
interefere in AB clearance
polymorphic effect
20 loci
low contribute poly moorphism
Rest
low
TYRBP
TREM2
macroglia receptor
AB clearance
Hallmarks
AB
NF tangles
neuro inflammation
insulin resistance
oxidative stress
cerebro vascualr defects
abnormaly folded A +tau
strongest evidence of PSN1E and 2
adherese to membrane receptors
mechanism not known
preventaion
block proteases that produce AB
inh beta secretase
not suceful in RCCT
inh gamma secretase
biomarkers
AB
accumaltion
t-tau
inh tolerance
p-tau
pathologic changes CSF blood
two kinds
Typic
memory problems
executive dysfunction
Atypic
language problem
visual
practice
epidemy
till 2025
each year twice
in last 20 years
age spicifity has lowerd
risk factors
cause the course of disease is long
dont know if risk factors really had an effect
roterdam study
30 percent for risk factors
CFNLPN
in ALS and dementia
men more than women
neuro axonal damage biomarker
FTD from AD and PD
AD
early
5%
PSN1-2 APP
late
95%
APOE4
Risk bala
AB clearance payin
G8
to find a cure till 2025
first criteria
1984
before that only diagnosed after death
IWG/NUA
new criteria after new methods
depression
dementia risk factor
increase
higher risk
microboim
mostly on animals
feces from mouse to mouse
disease
new similar diseases?
LATE
APP
metal transfer
redox
fibrin
colinergic theory
Anti colienergc adverse effects?
muscarini agonist for lowering AB and tau production pathways
Vaccine? / immuno threarpy?
mir 346
FLO