Please enable JavaScript.
Coggle requires JavaScript to display documents.
Background - Coggle Diagram
Background
Prevailing consensus
Oxidative damage
Mediated by hydroxyl radical (implicit transition metal ions)
Nebulous
Explanatory detail
No need to labor the point
Protein thiols
Define
Redox signalling
Pervasive pathological increase in thiol oxidation
New paradigm
Links to key phenotypes
Oxidative stress
Important
Link to oocyte quality
Key phenotypes
IVM suboptimal
Broad model
Electron oversupply (substrate)
Electron accepter (O2)
Unify to equation
Superoxide should give rise to hydrogen peroxide.
Critical gap is how H2O2 causes oxidative stress
ART
Importance
Infertility data
Success oocyte quality