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Haemostatic disorders - Coggle Diagram

- - - - Collection artefact
        
        Platelet aggregation
      - Disorders of production
        
        Drug toxicity
        
        Oestrogen ; phenylbutazone
        
        Myelopthisis
      - Abnormal distribution
        
        Rare
        
        Marked splenic congestion; neoplasia; DIC
      - Increased utilisation / destruction
        
        Immune mediated thrombocytopaenia (IMT)
        
        Primary
        
        Autoantibodies
        
        Against platelet autoantigens
        
        Targets megakaryocytes + platelets
        
        Secondary
        
        Uncommon
        
        Ab production from underlying condition
        
        neoplasia; infectious disease; drug
        
        Vaccine induced
        
        Modified live vaccines
        
        Mild; 3-10 days after
        
        Clinical bleeding with platelet defect
        
        Shortened lifespan
        
        Drug-induced
        
        Acute bacterial / viral infection; DIC
      - Disseminated intravascular coagulation (DIC)
        
        Associated signs
        
        Thrombotic disease
        
        Tissue hypoxia
        
        Multiple infarctions
        
        Consumptive coagulopathy
        
        Bleeding disorder
        
        Decreased platelets and clotting factors
        
        Increase fibrinolysis
        
        Secondary coagulation disorder
        
        Underlying disorders
        
        Neoplasia; Sepsis; Endotaxaemia
        
        Immune-mediated disease; intravasular haemolysis; shock
        
        Initial activation
        
        Widespread injury to endothelial cells
        
        Trauma; surgery; neoplasia; infections
        
        Microvascular thrombosis
        
        Tissue hypoxia and dysfunction
        
        Systemic inflammation
        
        Widespread bleeding
        
        Common in dogs
  - - - Inherited (rare)
      - Acquired
        
        Secondary condition
        
        Chronic liver/kidney disease
        
        Uraemia
        
        Acute massive hepatic necrosis / late chronic liver disease
        
        Myeloproliferative disorders
        
        Dysproteinaemia
        
        NSAIDs eg. aspirin
        
        Inhibit thromboxane synthesis
  - - - Most common canine hereditary bleeding disorder
      - Dobermans, German shephards; standard poodles; GR; Shetland sheepdogs
- - - - Coagulation factors II, VII, IX, X
      - Dysfunctional coagulation factors
      - Eg. Coumarins toxicity
- - - - Platelet plugging
      - Fibrinogen polymerisation
    - - Plasmin