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COVID-19 Spike Protein - Coggle Diagram
COVID-19 Spike Protein
SAR-COV-2
75-80% genetic similarity to COVID-19
Related to SARS-COV because they have the same spike protein that binds to human cells.
Human body does not make antibodies for this disease well.
Binds to ACE2
Receptor binding domain (RBD) allows the S-protein to attach to the ACE2 in the proteins open state.
Linear sequence of 1273 amino acids
RBD is amino acids 329-522
144 amino acids in common with SARS - CoV
Different from SARS-CoV in amino acids 437-461 and 469-487
https://www.ncbi.nlm.nih.gov/Structure/pdb/6VSB
https://www.ncbi.nlm.nih.gov/Structure/pdb/6LZG
Amino Acids
Similarity in amino acids=similarity in structure
SARS-COV
SARS-COV antibodies cannot recognize SARS_COV-2
1255 amino acids in length
RBD is amino acids 316-508
Looks good!