Treatment: Penicillamine (50mg/kg/day, PO, for 6days), Vitamin C (500mg/day/sheep, SC), Ammonium tetrathiomolybdate (1.7mg/kg, IV, every other day for 6 days), ammonium molybdate (100mg) and sodium thiosulfate (1g) PO for 3weeks in affected lambs, zinc acetate (250ppm)