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BIOSYNTHESIS OF PHOSPHOLIPID & CHOLESTEROL - Coggle Diagram
BIOSYNTHESIS OF PHOSPHOLIPID & CHOLESTEROL
SLO1 : Outline biosynthesis of phospholipids
PHOSPHOLIPIDS
GLYCEROPHOSPHOLIPIDS
FR PHOSPHATIDIC ACID & ALCOHOL
CARDIOLIPIN
BACKBONE = GLYCEROL
PLASMALOGENS
PLATELET-AACTIVATING FACTOR
SPHINGOPHOSPHOLIPIDS
BACKBONE = SPHINGOSINE
SPHINGOMYELIN
SYNTHESIS SAME LIKE SYNTHESIS OF TG
STH IN COMMON LIKE :-
FA
GLYCEROL
GLUCOSE
Hydrolize phosphodiester bond of phosphoglycerides
SYNTHESIS OF LECITHIN
CHOLINE
PHOSPHOCHOLINE
CDP -CHOLINE
ACTIVATE PHOSPHOCHOLINE
By PHOSPHOCHOLINECYTIDYLTRANSFERASE
CTP --> PPi
By CHOLINE KINASE
ATP --> ADP
DIACYLGLYCEROL
CDP - CHOLINE
LECITHIN (PHOSPHATIDYLCHOLINE)
By CHOLINEPHOSPHOTRANSFERASE
Release CMP
IN LIVER
Fr rx of phosphatidylethanolamine + AdoMet -->
S-adenosylhomocysteine
synthesis in MAMMALIAN TISSUE
Provided by BASE EXCHANGE RX
Ethanolamine of phosphatidylethanolamine
exchanged for FREE SERINE
W/ catalyst : phosphatidylethanolamine-serine transferase
BIOSYNTHESIS OF PHOSPHATIDYLINOSITOL
SYNTHESIZED BY :-
CDP-DIACYLGLYCEROL + INOSITOL
PHOSPHATIDYLINOSITOL
Release CMP
SLO2 : Explain role of different types of lipases
PHOSPHOLIPASE
A2
Present in :-
MAMMALIAN TISSUE
PANCREATIC JUICE
SNAKE VENOM
BEE VENOM
Activated by = TRYPSIN
Need BILE SALTS for activity
C
FOUND IN :-
A-TOXIN OF CLOSTRIDIA // BACILLI
LIVER LYSOSOMES
Activated by = PIP2 SYSTEM
FX : PRODUCE 2ND MESSENGER
A1
Present in = MAMMALIAN TISSUE
D
FX :
SIGNAL TRANSDUCTION
GEERATE PHOSPHATIDIC ACID
PHOSPHOLIPID
DEGRADATION
PHOSPHOLIPIDS
2-ACYL LYSOPHOSPHATIDE
By PHOSPHOLIPASE A1
Release H2O
1-ACYL LYSOPHOSPHATIDE
By PHOSPHOLIPASE A2
REMODELLING
By help fr phospholipase
CHOLESTEROL
CHOLESTEROL ESTER
By LCAT
LECITHIN
LYSOLECITHIN
By PHOSPHOLIPASE A2
ACYL CoA
CoASH
By ACYL TRANSFERASE
Important for synthesis of DPCC
PHOSPHATIDYLGLYCEROL
PHOSPHATIDYLINOSITOL
DIPALMITOYLLECITHIN
SURFACTANT PROTEINS