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BIOSYNTHESIS OF FA & TG - Coggle Diagram

- - - - source of acetyl coA from :-
        
        CATABOLISM OF FA / KETONE BODIES
        
        AEROBIC GLYCOLYSIS
        
        pyruvate
        
        oxidized to acetyl coA
        
        in mitochondria
        
        converted to CITRATE
        
        since cant cross mitochondria membrane
        
        migrate to cytosol
        
        2 more items...
        
        by CITRATE SYNTHASE
      - source of NADPH
        
        PENTOSE PHOSPHATE PATHWAY
        
        GLUCOSE
        
        G6P
        
        6-phosphoglucono-&-lactone
        
        6-phosphogluconate
        
        2 more items...
        
        H2O --> H+
        
        NADP+ --> NADPH + H+
        
        by HEXOKINASE
        
        MALIC ENZYME
    - - Catalyzed by ACETYL COA CARBOXYLASE
      - Has coenzyme BIOTIN to assist ACC
      - Need CO2 & ATP
      - FX ACC : to convert acetyl coA --> malonyl coA
      - HOW IS ACC REGULATED??
        
        SHORT TERM REGULATION
        
        METHOD 1
        
        INACTIVE ACC
        
        ACTIVATED
        
        ENHANCED BY CITRATE
        
        1 more item...
        
        METHOD 2
        
        INACTIVE ACC
        
        ACTIVATE
        
        ENHANCED BY INSULIN
        
        1 more item...
        
        LONG TERM REGULATION
        
        Prolong consumption of diet
        
        low calories
        
        synthesis of carboxylase is unregulated by insulin via SREBP-1