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Comparative Gene-omics, Comparative Gene-omics - Coggle Diagram

- - - - Orthologue - type of homologous gene that diverges after speciation
        
        Xenologue - A type of ortholog where the homologous sequences are found in different species because of horizontal gene transfer.
        
        Lecture 22, slide 25
      - Paralogue - type of homologous gene that diverges after duplication of gene, leading to different functions in each due to environmental selection pressures.
      - Group homologous proteins - based on sequence similarity, synteny and operons
        
        Should be able to differentiate between true homologues (orthologues) and paralogues
        
        Should be able to find the orthologues within paralogous sequences.
        
        Should have good annotation quality - consider missing genes, false genes
        
        Lecture 22, slide 26
- - - - Annotate all genes produced from previous step, even if some of them are already found in database, to maintain consistency of annotation process for all genes.
      - Pan-Genome arrangement - Roary
        
        Visualize - Phandango
        
        matrix or spreadsheet format delineating core, dispensable (accessory) and isolate-specific genes
        
        Lecture 22, slide 28-32
        
        analysis of gene level causation of phenotypes