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Factor V Leiden Thrombophilia - Coggle Diagram
Factor V Leiden Thrombophilia
Symptoms
Having a first DVT or PE before 50 years of age.
Having recurring DVT or PE.
Having venous thrombosis in unusual sites in the body such as the brain or the liver.
Having a DVT or PE during or right after pregnancy.
Having a history of unexplained pregnancy loss in the second or third trimester.
Having a DVT or PE and a strong family history of venous thromboembolism.
What is factor V Leiden Thrombophilia?
It is an inherited disorder of blood clotting.
Factor V Leiden is the name of a specific mutation (genetic alteration) that results in thrombophilia, or an increased tendency to form abnormal blood clots in blood vessels.
People who have the factor V Leiden mutation are at somewhat higher than average risk for a type of clot that forms in large veins in the legs (deep venous thrombosis, or DVT) or a clot that travels through the bloodstream and lodges in the lungs (pulmonary embolism, or PE).
Factor V Leiden is the most common inherited form of Thrombophilia.
How is it diagnosed?
The diagnosis is made using a screening test called a coagulation screening test or by genetic testing (DNA analysis) of the F5 gene.
By looking at history of venous thrombosis and/or a family history of venous thrombosis.
Treatment
People with factor V Leiden who have had a DVT or PE are usually treated with blood thinners, or anticoagulants.
Individuals are counseled about reducing or eliminating other factors that may add to one's risk of developing a clot in the future.
Individuals may require temporary treatment with an anticoagulant during periods of particularly high risk, such as major surgery.