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(Эпилепсия) - Coggle Diagram

- - - - activities arise mainly within the supragranular cortical layers of the peritumoral neocortex infiltrated by glioma cells but not in the glioma core
        
        Pallud J, 2014
      - слой между корой и перитуморальной зоной :!:
      - степень вовлеченности коры коррелирует с частотой эпилепсии
      - изменения в коре
        
        :!!: neuronal loss, glial loss, neurogenesis, reactive astrogliosis, neuronal plasticity
        
        Beaumont A, 2000; de Groot M, Reijneveld JC, 2012, Shamji MF, Fric-Shamji EC, 2009
        
        :silhouette:Семьянов А.В.
        
        alterations in local neuronal, networks, resulting in a reduction of inhibitory, pathways and an increase of excitatory ones.
        
        для ГБМ при нарушении ГЭБ - поступление в головной мозг blood serum components, such as glutamate, fibrin- ogen, and albumin
        
        Buckingham SC, Robel S, 2013
    - - механическое воздействие
      - ишемия в перитуморальной области
      - deafferenta-tion of the corticosubcortical local and distant net- works, leading to epileptogenicity
      - локализация опухоли
    - - IDH
        
        conversion of isocitrate to D-2-hydroxyglutarate rather than to a- ketoglutarate.
        
        D-2-hydroxygluta is thought to act as a glutamate receptor agonist
        
        более высокая частота встречаемости эпилепсии при LGG
        
        :silhouettes: Ширманова М., Лукина М.
      - excessive local glutamatergic excitatory neurotransmission
        
        facilitation of patho- logic pyramidal cells synchronization.40 Experi-induce seizures through the facilitation of patho- logic pyramidal cells synchronization.40
      - глутамат
        
        DLLG
        
        D-2-hydroxygluta is thought to act as a glutamate receptor agonist
        
        HGG
        
        выброс глутамата клетками опухоли
      - GABA
        
        weakening of GABAergic inhibitory function within peritumoral neocortex
        
        GABA-mediated disinhibition of surrounding pyramidal cells
      - mTOR pathway
        
        tumor growth into peritu- moral brain likely results in glioma epileptogenesis, whereas neuronal activity in a peritumoral brain may in turn promote tumor proliferation, resulting in a vicious cycle of tumor progression and morbidity
  - - - когнитивные нарушения
      - качество жизни
    - - взаимодействие с химиотпрепаратами
      - возможное прямое онкологическое действие