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Loop Diuretics, Side Effects, NSAIDs - Coggle Diagram
Loop Diuretics
Mechanism
Of Action
Site
of action
Receptor
NKCC
Na/K/2Cl cotransporter
Luminal Membrane
Thick Asc. Limb of LoH
BLOCK
Na/K/Cl transport
out of
LoH
Retention of
Na, K, Cl
in
Lumen
ROMK Channels
Reduced return of [K]
to Lumen
Lumen +ve Potential ↓
Lumen remains
neutrally charged
Cations
[Ca, Mg]
not reabsorbed
↑ Intraluminal Osmolarity
↓ Medullary Osmolarity
Diuresis
Volume Depletion
Hyperuricemia
Contraction alkalosis
Cations excreted
Hypokalemia
Hypomagnesemia
Hypocalcemia (rare)
Alternate mechanism
Induce expression
COX-2
Prostaglandin
synthesis
Inc salt excretion
Dilated
Afferent
Indications
Heart Failure
Pulmonary edema
Fluid overload
Liver failure
Ascites
Hypertension
Examples
Furosemide
Ethacrynic Acid
Side Effects
Ototoxicity
Interstitial Nephritis
(Sulfa drug)
NSAIDs