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muscle relaxants - Coggle Diagram
muscle relaxants
peripheral
neuromuscular blocking agent
--> curare
fast distribution, lower elimination
indications :check:
- facilitate intubation
- facilitate mechanical ventilation
- optimized surgical working conditions
depolarizing
-
action :question: :
- physically ressemble Ach
- act as Ach receptor agonist
- depolarizing action perisist > Ach
- continuous end - plate depolarization causes muscle relaxation
side effect :red_cross:
- CV
- fasiculation
- muscle pain
- increase intraocular/ gastric / cranial pressure
- hyperK
- malignant hyperthermia
non depolarizing
-
action :question: :
- compete with Ach at binding sites
- do not depolarized the motor endplate
- competitive antagonist
- excessive [] causing channel blockade
- act at presynaptic sites, prevent mvt of Ach to release sites
antagonisation
--> anticholinesterases
- neostigmine
- pyridostigmine
- edrophonium
central
-
non benzodiazepines
-
action :question: :
- potentiation of GABA transmission (baclofen)
- stimulation of alpha 2 adrenergic receptors (tizanidine)
- stimulation of glycinergic transmission (thiocolchicoside)
- inhibition of voltage gated Na channels (tolperisone)
...
indications :check:
- acute back pain caused by spasms of skeletal muscle
- chronic painful conditions but for short term use
- additive effect with NSAIDs or paracetamol