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Перифокальная область - Coggle Diagram

- - - - Burger, P.C.; Dubois, P.J.; Schold, 1983
- - - - лимфатическая система
        
        Louveau, A.; Smirnov, I., 2015
    - - плохой прогноз Shi, Y.; Ping, Y.F. 2017; Roesch, S.; Rapp, C.; Dettling, 2018
      - обеспечивают инвазивность
    - - угнетают Т-клеточный ответ
        
        Haile, L.A.; Greten, T.F.; 2012
      - плохой прогноз в солидных опухолях Zhang, S.; Ma, X.; 2016
    - - NK cells
        
        GBM escapes NK immune surveillance
        
        GBM-infiltrating NK cells are non-functional
      - GBM-Infiltrating Lymphocytes (TILs)
        
        positively associated with a longer clinical survival
  - - - апоптоз
      - пролиферация и клеточный цикл
      - the remodeling of the extracellular matrix, tumor infiltration and angiogenesis
      - инвазивность
      - поддержание стволовых клеток (stem-cell renewal)
      - восстановление ДНК
      - ссылки D’Alessio, Alessio
        Proietti, Gabriella, 2019
  - - - border between GBM and the non-invaded brain tissue
        
        Haybaeck, J.; Obrist, P., 2007
    - - GBM and apparently normal peritumoral cells share a similar gene expression profil
        
        Mangiola, A.; Saulnier, N., 2013
    - - D’Alessio, Alessio
        Proietti, Gabriella, 2019
  - - - anti-angiogenesis drug
        as bevacizumab (Avastin) - a monoclonal antibody against VEGF
    - - MVD ocated at a greater distance from the tumor margin correlates with the median patient survival time
        
        Sica, G.; Lama, G.; Anile, 2011
    - - Sica, G.; Lama, G.; Anile, 2011
- - - - воспаление
        
        рост опухоли
- - - - Lemee J.-M., Clavreul A., 2015
- - - - ссылки Zetterling, Maria
        Roodakker, Kenney R., 2016
    - - Price SJ, Jena R, 2006
  - - - Zetterling, Maria
        Roodakker, Kenney R., 2016
- - - - см. ссылки Zetterling, Maria
        Roodakker, Kenney R., 2016
        
        :!!: ОКТ снижение сигнала коррелировать с инфильтрацией
      - :pencil2:провести ОКТ сканирование enbloc резецированной ткани для составления карты инфильтрации
    - - limited infiltration of the white matter reflects an early stage of tumor invasion
  - - - The short and intracortical U-fibers are the most probable way of diffusion for tumor cells between 2 adjacent gyri
      - Zetterling, Maria
        Roodakker, Kenney R., 2016
- - - - Duffau H: The challenge to remove diffuse low-grade glio- mas while preserving brain functions. 2012
      - Yordanova YN, 2011
    - - онкологическое
        
        остаются опухолевые клетки
        
        Zetterling, Maria, 2016
    - - surgical brain injury (SBI)
    - - Pallud, Johan
        McKhann, Guy M., 2019
      - is a primary predictor of postoperative seizure control in DLGG patients
        
        uncontrolled seizures in 44% following biopsy, in 40% following partial resection, in 32% following subtotal resection, and in 16% following total resection
        
        Pallud J, Audureau E., 2014
      - Pallud J, Varlet P,, 2010
- - - - activities arise mainly within the supragranular cortical layers of the peritumoral neocortex infiltrated by glioma cells but not in the glioma core
        
        Pallud J, 2014
      - слой между корой и перитуморальной зоной :!:
      - степень вовлеченности коры коррелирует с частотой эпилепсии
      - изменения в коре
        
        :!!: neuronal loss, glial loss, neurogenesis, reactive astrogliosis, neuronal plasticity
        
        Beaumont A, 2000; de Groot M, Reijneveld JC, 2012, Shamji MF, Fric-Shamji EC, 2009
        
        :silhouette:Семьянов А.В.
        
        alterations in local neuronal, networks, resulting in a reduction of inhibitory, pathways and an increase of excitatory ones.
        
        для ГБМ при нарушении ГЭБ - поступление в головной мозг blood serum components, such as glutamate, fibrin- ogen, and albumin
        
        Buckingham SC, Robel S, 2013
    - - механическое воздействие
      - ишемия в перитуморальной области
      - deafferenta-tion of the corticosubcortical local and distant net- works, leading to epileptogenicity
      - локализация опухоли
    - - IDH
        
        conversion of isocitrate to D-2-hydroxyglutarate rather than to a- ketoglutarate.
        
        D-2-hydroxygluta is thought to act as a glutamate receptor agonist
        
        более высокая частота встречаемости эпилепсии при LGG
        
        :silhouettes: Ширманова М., Лукина М.
      - excessive local glutamatergic excitatory neurotransmission
        
        facilitation of patho- logic pyramidal cells synchronization.40 Experi-induce seizures through the facilitation of patho- logic pyramidal cells synchronization.40
      - глутамат
        
        DLLG
        
        D-2-hydroxygluta is thought to act as a glutamate receptor agonist
        
        HGG
        
        выброс глутамата клетками опухоли
      - GABA
        
        weakening of GABAergic inhibitory function within peritumoral neocortex
        
        GABA-mediated disinhibition of surrounding pyramidal cells
      - mTOR pathway
        
        tumor growth into peritu- moral brain likely results in glioma epileptogenesis, whereas neuronal activity in a peritumoral brain may in turn promote tumor proliferation, resulting in a vicious cycle of tumor progression and morbidity
  - - - когнитивные нарушения
      - качество жизни
    - - взаимодействие с химиотпрепаратами
      - возможное прямое онкологическое действие