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Toxicokinetics - Coggle Diagram
Toxicokinetics
Absorption
Bioaccumulation: Net accumulation of a contaminant by an organism via environmental sources
Air
Soil/Sediments
Food
Water
Bioconcentration: when concentrations of a chemical in fish/aquatic organisms surpasses the concentration in the water
BCF = [Concentration in fish] / [Concentration in water]
Biomagnification: concentration of a chemical increases as it moves up the food chain
Particles entering a substance
3 Routes of entry
Aqueous
Endocytic
Lipid
Distribution
Toxicants travel through blood stream
Hydrophilic toxicants: adhere to plasma
Lipophilic toxicants: adhere to blood cells
Will travel to other organs and tissues
Biotransformation
Toxicant gets altered upon entering organism
Elimination
Transforms into hydrophilic compound
Detoxification
Toxicant becomes inactivated
Activation
Increase in toxicity
Sequestration
Redistribution
Toxicant will transfer to different organ/tissue
Elimination/Excretion
Chemical leaves organism
Animals
Feces
Bile
Urine
Lungs/Gills
Plants
Evaporation from surfaces
Leaf fall
Leaching
Invertebrates
i.e. Anthropods
Exoskeleton molting