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Prehension disorders from infectious agents 2 - Coggle Diagram

- - - - Hypervirulent
        
        Highly pathogenic
        
        Widespread disease
        
        Bronchointerstitial pneumonia
        
        Necrosis
        
        Pancreatic, hepatic, splenic
        
        Coagulopathy - bruising and bleeding
        
        High mortality rates
        
        Sudden death
        
        Vaccines ineffective
    - - Polyarthritis
        
        Synovial membrane thickening
        
        Increased synovial fluid
    - - Vesicle formation
        
        Host Cell lysis releases virions
        
        Ulcerations
        
        Secondary bacterial infections
        
        Oral cavity + nasal plate
        
        Neutrophil infiltration
        
        Prolonged carrier status: <2 years
      - Incubation :1-5 days
  - - - Antigenic variation
        
        Virulent trophism
        
        Mutation - avoid host immune response
      - Environmental stability
    - - Oral; URT; Conjunctiva
  - - - Oral ulcers; facial oedema
      - Upper respiratory tract illness
        
        Serous nasal discharge
        
        Chemosis + conjuctivitis
      - Virulent systemic FCV associated
        
        High fever, head and limb oedema
        
        Hair loss, skin ulceration - ears, pawpads
  - - - Incomplete protection
        
        Decreases disease severity
    - - Kills norovirus
      - Sodium hypochlorite
        
        Bleach
      - Alcohol
        
        1-propanol
        
        70% ethanol
- - - - Environmental stability
        
        <6 months
      - Antigenic variation
        
        Vaccination limited
        
        Evade host immune system
    - - Cloven hoof animals
  - - - Cell lysis in multiple body sites
        
        Shedding of virus - large amounts
        
        Highly infectious
        
        Superficial locations
      - Cellular function shutdown
    - - Rapid replication (5-10 hrs)
        
        Carrier status
      - Shedding precedes clinical signs
  - - - Fever; epithelial vesicles
        
        Ruptured, ulcerated
        
        Secondary bacterial infection
        
        Sharp edges
        
        Raw appearance, extensive fibrin infill
      - Pain - mouth, feet teats
        
        Dental pad; tongue
        
        Interdigital spaces (cloven foot)
        
        Pig trotters more severely affected
      - Low mortaility, high morbidity
        
        Young animals: Acute myocarditis
  - - - Geographical serotype
        
        Minimal cross protection
      - Short term immunity
    - - High infectivity