Excipients Used in Softgel Manufacture - Coggle Diagram
Excipients Used in Softgel Manufacture
Provides structural support for the softgel
Used to make softgels elastic and pliable
Generally account for 20-30% of the wet gel formation and include propylene glycol, glycerol and sorbitol
Generally accounts for 30-40% of wet gel formulation
Ensures proper processing during gel preparation and encapsulation
Excess water is removed from softgels using controlled drying.
FD&C water-soluble dyes, lakes, pigments and vegetable colours can be used.
Colour of the capsule shell should be similar to or darker than the fill inside.
Opacifiers are sometimes used to produce an opaque shell for a suspension fill or a fill that contains light-sensitive ingredients. Titanium dioxide is most commonly used.
polyethylene glycols and non-ionic surfactants (polysorbates)
Used to prepare the fill of the softgel
Drugs that are not sufficiently soluble are formulated into suspensions