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ApoE - Coggle Diagram
ApoE
ApoE4
amyloid beta (AB)
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ApoE4 carriers show a poor compensation of neuronal loss in different brain regions, whereas non-e4 carriers exhibit marked regenerative changes in the same areas [140 in Maioli, S. (2011). Interaction between APOE4 genotype and environmental risk factors in Alzheimer's disease (Doctoral dissertation, alma).]
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impairment of Reelin--helping regulating processes of neuronal migration and positioning in the developing brain by controlling cell-cell interactions
hampering balance to inhibit effects of AB on LTP [72 in Lane-Donovan & Herz, 2017)
weakening the ability of reelin to protect against the deleterious effects of amyloid beta on the synapse (Lane-Donovan, 2017)
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reduced levels of insulin-degrading enzyme (IDE) (Du et al., 2009)
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ApoE2
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an active role in inhibiting AB aggregation or favouring AB clearance [125-126 in Maioli, S. (2011). Interaction between APOE4 genotype and environmental risk factors in Alzheimer's disease (Doctoral dissertation, alma)].
ApoE3
an active role in inhibiting AB aggregation or favouring AB clearance [125-126 in Maioli, S. (2011). Interaction between APOE4 genotype and environmental risk factors in Alzheimer's disease (Doctoral dissertation, alma)].
might be able to prevent abnormal tau hyperphosphorylation and destabilization [130 in Maioli, S. (2011). Interaction between APOE4 genotype and environmental risk factors in Alzheimer's disease (Doctoral dissertation, alma)]