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Mucosal immune system - Coggle Diagram
Mucosal immune system
黏膜免疫細胞的循環
redistribution of effector T cells
導引淋巴細胞至小腸的分子機制
CCL25(小腸)
CCL28(大腸)
MAdCAM-1
αE:β7
dendritic cells produce retinoid acid
Priming of naïve T cells
Common mucosal immune system
不同的樹突細胞群控制黏膜免疫反應
Peyer’s patch dendritic cells
Express CD11b integrin→Th17 cells
IL-10 in steady stage
IL-23 in inflammatory
促進Th17 cells發育
刺激ILC3 cells
produce IL-17 and IL-22
嗜中性球聚集
CCR6
CD11b-negative cells
IL-12
促進Th1 cells發育
dendritic cells進入Mesenteric lymph nodes
產生FoxP3+ regulatory T cells
assisted by TGF-β
mucosal DCs抗發炎反應的環境分子
PGE2
IL-10
TSLP、TGF-β
Retinol
共生菌Commensal bacteria
共生菌抑制發炎的機制
在腸道及系統免疫的影響
腸道關於共生菌的調控
黏膜免疫系統的細胞和其分布
Organized secondary lymphoid tissues
Gut-associated lymphoid tissue:
isolated lymphoid follicles
the tonsils and adenoids
Peyer’s patch
Mesenteric lymph nodes
Scattered lymphocytes
epithelium
CD8細胞為主
Express CCR9
Express Type A and Type B form
Express integrin (CD130)
腸道上皮細胞的 innate defense
NOD
TLR
inflammasome
autophagosome
lamina propria
CD4細胞為主
腸道獨特的抗原攝取機制
mononuclear cells
M cells
Transcytosis
腸道巨噬細胞消除病原體
分泌IL-10維持黏膜的 antigen-specific tolerance
身為scavenger不引發發炎反應