Please enable JavaScript.
Coggle requires JavaScript to display documents.
Musculoskeletal, skin and connective tissue pharmacology - Coggle Diagram
Musculoskeletal, skin and connective tissue pharmacology
arachidonic acid pathway
membrane phospholipid
arachidonic acid
-
cyclic endoperoxides (catalyzed by COX1,2)
-
-
-
acetaminophen
for antipyretic(解熱剤), analgesic(鎮痛剤), not anti-inflammatory, used to instead of aspirin in children
-
inhibit cycloxygenase(COX), mostly in CNS
aspirin
low dose→↓platelet aggregation; intermediate dose→antipyretic and analgesic; high dose→anti-inflammatory
adverse: gastric ulceration, allergic reaction, acute renal failure, interstitial nephritis, GI bleeding
-
-
celecoxib
for rheumatoid arthritis, osteoarthritis
inhibit COX2 only, not have corrosive effect on GI, spare TXA synthesis
-
leflunomide
for rheumatoid arthritis, psoriatic arthritis
reversibly inhibit dihydroorotate dehydrogenase, preventing pyrimidine synthesis, supress T cell proliferation
bisphosphonate
for osteoporosis, hypercalcemia, Paget disease, etc
pyrophosphat analog, bind hydroxyapetite in bone, inhibiting osteoclast activity
-
Gout drug
-
acute gout drug
-
colchicine
-
adverse: GI, neuromyopathic effects
-
TNF-α inhibitor
etanercept
for rheumatoid arthritis, psoriasis, ankylosing spondylitis
fusion protein, produced by recombinant DNA
infliximab, adalimumab, certolizumab, golimumab
-
for IBD, rheumatoid arthritis, ankylosing spondylitis, psoriasis