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Pancreas pathology - Coggle Diagram
Pancreas pathology
Developmental anomalies
Pancreatic hypoplasia
Juvenile pancreatic atrophy
Autoimmune reaction
Exocrine reduction
Ducts
Variation in duct disposition (Dog)
Entering duodenum
Pancreatic bladder (cats)
Sacculation of ductule system
Polycystic kidneys / cystic bile ducts
Cystic pancreatic ducts
Displaced accessory / ectopic pancreatic tissue
Found in associated organs :
Pancreatitis (necrosis from self-digestion)
Acute
Lesions
Haemorrhage ; Oedema; fibrin exudate
Fat necrosis; coagulation necrosis; lipid droplets
Released inflammatory mediators
Systemic effects
Neutrophils + macrophages
Self-digestion
Clinical signs: Abdominal pain; vomit; diarrhoea; inappetance
Chronic
Lesions
Atrophic lobules
Fibrosis
Increased interstitial space
Loss of islets
Exocrine insufficiency
Diabetes mellitus
Chronic interstitial pancreatitis
Ascending bacteria ; fluke migration
Ductule fibrosis
Cats and horses
Causes
Intracellular transport defects
Intracellular activation of enzymes
Direct acinar injury
Ischemia; toxic ; direct trauma
Duct obstruction
Increased intraductal pressure
Accumulation of activated enzymes
Neoplastic
Pancreatic carcinoma
Metastasise to associated organs
Pancreatic endocrine neoplasia
Invasion into exocrine tissue
Pancreatic nodular hyperplasia
Diabetes mellitus
Classification
Type 1
Insulin deficiency
Congenital in dogs
Immune mediated loss of beta cells
Viral infection of cattle
Type 2
Reduced insulin sensitivity
Peripheral tissues
Continuous hyperglycaemia
Amyloid deposition in cats
Inadequate insulin secretion
Type S
Insulin function antagonised by hormones / drugs
Eg. GCS
Hyperglycaemia
Impaired glucose uptake by cells