Chapter 26 Hormones and the endocrine system

26.1 Chemical and electrical signals coordinate body functions

The endocrine system is a group of interacting glands and tissues that pro- duce and secrete chemicals to initiate and maintain body functions.

Hormones are chemical signals released by endocrine cells, which travel in the bloodstream to all parts of the body.

Hormones are made and secreted mainly by organs called endocrine glands.

The hormone can travel by the circulatory system to all parts of the body, but only some types of cells, called target cells, have receptors for that specific hormone.

Specialized neurons called neurosecretory cells perform functions in both endocrine and the nervous system.

26.2 Hormones affect target cells using two main signaling mechanisms

Water-soluble hormone

1.A water-soluble hormone molecule binds to the receptor protein, activating it.

2.This initiates a signal transduction pathway, a series of changes in cellular proteins that converts an extracellular chemical signal to a form that can bring about a response inside the cell.

3.The final relay molecule activates a protein that carries out the cell’s response, which may occur in the cytoplasm or in the nucleus .

Lipid-soluble Hormones

1.a lipid- soluble hormone enters a cell by diffusion.

2.The hormone binds to an open receptor protein in the cytoplasm or nucleus. Rather than triggering a signal transduction pathway with relay proteins, the hormone-receptor complex itself usually carries out the transduction of the hormonal signal.

3.The hormone-receptor complex attaches to specific sites on the cell’s DNA in the nucleus.

4.The binding to DNA stimulates gene regulation, turning genes either on or off.

26.3 a widely used weed killer demasculinizes male frogs

Endocrine disruptors are substances that interfere with the endocrine system’s normal functions.

Such chemicals can potentially enter animal cells, altering the normal ratio of sex hormones.

26.4 The vertebrate endocrine system consists of more than a dozen major glands

Pineal gland

Melatonin - participates in regulation of biological rhythms.

Hypothalamus

Multiple hormones from the hypothalamus directly control the pituitary gland.

Thyroid gland

Thyroid hormone - stimulates and maintains metabolic processes.

Calcitonin - lowers blood calcium level.

Pituitary gland

Anterior pituitary

Many hormones affect the activity of other endocrine glands and cells of the body.

Posterior pituitary

Oxytocin - stimulates contraction of uterus and mammary gland cells.

Antidiuretic hormone (ADH) - promotes retention of water by kidneys.

Testes (in males)

Androgens - support sperm formation; promote development and maintenance of male secondary sex characteristics.

Ovaries (in females)

Estrogens - stimulate uterine lining growth. They promote development and maintenance of female secondary sex characteristics.

Progesterone - promotes uterine lining growth.


Adrenal glands (atop kidneys)

Adrenal medulla

Epinephrine and norepinephrine - raise blood glucose level. They also increase metabolic activities. And lastly, they constrict certain blood vessels.

Adrenal cortex

Glucocorticoids - raise blood glucose level.

Mineralocorticoids - increase blood volume and blood pressure.

Pancreas

Insulin - lowers blood glucose level.

Glucagon - raises blood glucose level.

The pineal gland, a pea-sized mass of tissue near the center of the brain, synthesizes and secretes melatonin, a hormone that links environmental light conditions with biological rhythms, particularly the sleep- wake circadian rhythms.

26.5 The hypothalamus, which is closely tied to the pituitary, connects the nervous and endocrine systems

The hypothalamus is the main control center of the endocrine system.

The pea-sized pituitary gland consists of two distinct parts: a posterior lobe and an anterior lobe.

The posterior pituitary is composed of nervous tissue and is actually an extension of the hypothalamus.

the anterior pituitary is an endocrine gland that both synthesizes and secretes hormones.

A releasing hormone stimulates the anterior pituitary to secrete more specific hormones and an inhibiting hormone induces the anterior pituitary to stop secreting more specific hormones.

Thyroid-stimulating hormone (TSH) regulates hormone production by the thyroid gland.

Prolactin (PRL) directly stimulates the mammary glands to produce milk. It has diverse effects in other vertebrates, such as the promotion of reproductive-related behaviors in birds and amphibians and the regulation of water balance in fish

One pituitary secretion with very broad
effects is the protein called growth
hormone
(GH).

The hypothalamus secretes a releasing hormone known as TSH-releasing hormone.

26.6 The thyroid regulates development and metabolism

Thyroid gland controls...

Thyroid hormone performs several important homeostatic functions and stimulates metabolism in virtually all the tissues of the body.

Insufficient iodine in the diet can cause goiter, an enlargement of the thyroid.

26.7 The gonads secrete sex hormones

The gonads, or sex glands, secrete sex hormones in addition to producing gametes.

In human, estrogens maintain the female reproductive system and promote the development of female features including breasts and wider hips.

In all mammals, progesterone is primarily involved in preparing and maintaining the uterus to support an embryo.

Mostly, androgens stimulate the development and maintenance of the male reproductive system

the main androgen is testosterone.

26.8 Pancreatic hormones regulate blood glucose level

The pancreas is a gland with dual functions

It secretes digestive enzymes into the small intestine.

it secretes two protein hormones, insulin and glucagon, into the blood.

They are said to be antagonistic hormones because the effects of one oppose the effects of the other.

26.9 diabetes is a common endocrine disorder

Diabetes mellitus is a serious hormonal disorder caused by the body’s inability to produce or use insulin, thereby decreasing the absorption of glucose from the blood.

Hyperglycemia is an elevated level of blood glucose.

Hypoglycemia is when blood glucose level drop below normal.

26.10 The adrenal glands mobilize responses to stress

The endocrine system includes two adrenal glands, which sit on top of each kidney.

made up of two glands fused together

A central portion called the adrenal medulla

An outer portion called the adrenal cortex.

Epinephrine - adrenaline.

Norepinephrine - noradrenaline.

Adrenocorticotropic hormone (ACTH) stimulates cells of the adrenal cortex to synthesize and secrete a family of steroid hormones called the corticosteroids.

Mineralocorticoids act mainly on salt and water balance.

Glucocorticoids function mainly in mobilizing cellular fuel. It promote the synthesis of glucose from noncarbohydrates such as proteins.

26.11 a single hormone can perform a variety of functions in different animals

Diverse functions have evolved for hormones.

26.12 Hormones can promote social behaviors

Oxytocin plays a part in mammalian social behaviors.