Diabetes

Types

Diabetes m type 1.

Diabetes m type 2

Diabetes insipidus

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Action if insulin

Stimulates fat storage by stimulating lipoprotein lipase which hydrolysed tG in vdl hence liberating fatty acids

Increase glucose uptake by updegulating glut 4 transporter in liver fat and muscle tissue

Stimulates glucagon synthesis

Stimulates lipogebesis II’m liver

Inhibits fatty acid oxidation and hence ketone synthesis in liver

Inhibits Lipolysiss in fat cells

Inhibits hormone sedative lipase in fat cells causing lipid storage

Hyperglycaemia

Glucose level fasting of 126

Symptoms of hyperglycaemia plus 200

200mg/drafter dose of 75mh/dl

Hyperglycaemia caused

Symptoms

Decrease response to insulin by tissues

Decreased production of insulin

Increased production of counter regulatory hormones

Eithiology

Nutritional excess from any source causes excess fatty acids to be stored at TGin adipose tissues

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Acute

Chronic

Hyperglycaemia causes surpassing of renal reabsorption threashold causing excretion of glucose and with it g2o and we se polyuria and the increase in fluid excretion causing dehydration and weight loss

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