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Hematology basic science, Anatomy, Physiology - Coggle Diagram
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Anatomy
thrombocyte
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vWF receptor: GpⅠb, fibrinogen receptor: GpⅡb/Ⅲa
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erythrocyte
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anisocytosis=varying size, poikilocytosis=varying shape
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neutrophil
azurophilic granules contain proteinase, acid phosphatase, myeloperoxidase, β-glucuronidase
granules contain leukocyte alkaline phosphatase (LAP), collagenase, lysozyme, lactoferrin
phagocytic, multilobed nucleus
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chemotactic agents: C5a, IL-8, LTB₄, kallikrein, platelet-activating factor
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macrophage
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phagocytose bacteria, cellular debris, senescent(老いた) RBCs
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Kupffer cell in liver, histiocyte in connective tissue, Lngerhans cells in skin, osteoclast in bone, microglial cell in brain
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mast cell
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activated by tissue trauma, C3a, C5a, surface IgE crosslinking by antigen→degranulation→release of histamine, heparin, tryptase, eosinophil chemotactic factor
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eosinophil
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produce histaminase, major basic protein, eosinophil peroxidase, eosinophil cationic protein, eosinophil derived neurotoxin
T cell
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differentiate into cytotoxic T cell, helper T cell, and regulatory T cell
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B cell
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B cell differentiate into plasma cell and memory cell, when antigen is entered
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plasma cell
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clock-face chromatin distribution, eccentric nucleus, abundant RER, well developed Goldi
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monocyte
large, frosted glass(すりガラス) cytoplasm
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lymphocyte
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round, densely staining nucleus with small amount of pale cytoplasm
leukocyte
neutrophil (60%), lymphocyte (30%), monocyte (6%), eosinophil (3%), basophil (1%)
granulocyte (neutrophil, eosinophil, basophil, mast cell), mononuclear cell (monocyte, lymphocyte)
basophil
basophilic granules contain heparin, histamine
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Physiology
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coagulation pathway
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combined: Ⅹ,Ⅴ,Ⅱ(prothrombin), Ⅰ(fibrinogen),ⅩⅢ
HMWK→bradykinin: ↑vasodilation, permeability, pain
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fetal erythropoiesis
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hemoglobin development
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have higher affinity for O₂ due to less avid binding of 2,3-BPG, allowing HbF to extract O₂ from maternal hemoglobin
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