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RNA VIRUS 1 - Coggle Diagram

- - - - linked with cord to RNA
      - VP 4
  - - - Overview
        
        Grup A
        
        myositis
        
        flaccid paralysis
        
        23 serotype
        
        Grup B
        
        pancreatitis, myocarditis, encephalitis (saraf pusat), hepatitis
        
        6 serotype
        
        irregular muscle
      - Pato
        
        transmisi : kontak langsung, fecal oral, droplets
        
        replikasi pada CNS - virus tersebar - gejala
      - antitoksin(suportif/terapi)
      - Manifestasi Klinis
        
        neurologic
        
        skin dan mukosa
        
        cardiac
        
        ocular
        
        respiratory
        
        GIT
        
        other
    - - infeksi pada manusia dan primata
      - immunodeficient dapat berperan sbg sumber infeksi
      - poliomyelitis --> flaccid paralysis
      - 3 tipe
      - Epidemiology
        
        Prevaccine era
        
        Vaccine era
        
        anak-anak lebih rentan
        
        negara berkembang --> infant (paralysis)
        
        negara maju --> toddler
        
        transmisi fecal oral
        
        berhubungan dg hygene
      - Patogenesis
        
        Alimentary phase
        
        bereplikasi di
        oropharynx(survive)
        
        Lymphatic phase
        
        replikasi di lymph node
        
        Viremic phase
        
        viremia 1
        
        Neural phase
      - Manifestasi Klinis
        
        Abottive poliomyelitis
        
        recovers dlm beberapa hari
        
        fever, malaise, nausea,vomiting, headache, constipation, drowsiness,sore throat
        
        Non paralytic poliomyelitis
        
        fast healing dan complete dlm 2-10 hari
        
        Paralytic poliomyelitis
        
        terjadi kerusakan pada lower motor neuron
        
        penyembuhan selama 6 bln
        
        Progressive postpoliomyelitis muscle atrophy
        
        komplikasi paralytic
        
        fungsi neuromuscular hilang
      - Diagnosis
        
        sample: throat swabs
        
        PCR
        
        serology : deteksi antibody
        
        Viral isolation
  - - - Transmisi : kontak langsung
      - dapat hidup beberapa jam pada objek tertentu
      - Sering pd anak : sal. nafas
    - - masuk melalui respiratory--> replikasi
        pada surface mukosa dari sel epitel hidung --> meningkatkan sekret hidung
- - - - chronic infection(70-90%)
      - achronic active hepatitis and cirrhosis
      - oncogenic
      - High genomic diversity
      - undergous sequence variation
- - - - gp 120 dan gp 41
  - - - protozoa
      - fungi
      - bakteri
      - virus
    - - kontak sexual
      - blood
      - jarum suntik
      - vertical : dari ibu ke bayi
      - High risk group
        
        homosexual
        
        multiple sexual
        
        partners
        
        drug abusers
        
        repeated transfusions
      - Laboratory
        
        viral load
        
        serology
        
        ELISA
        
        IF
        
        western blot
        
        immunology
      - HIV Terapi
        
        Against virus --> ARV
        
        Immunomodulator
        
        Against opportunistic
        
        Supportive therapy
      - Prevention
        
        Theoretically
        
        safe sex education
        
        donor selection
    - - infeksi dari HIV bisa alteration the fuction of innate and adaptive immunity karena CD4 sangat penting u/ keduanya.
      - kasus berat
        
        kaposy sarcoma
        
        persistent fever, night sweat, chronic diarrhea, decrease body weight, lymphadonepathies
      - masuk ke tubuh--> menyerang CD4 --> gp4 facillitates membran fusion between virion and cells (CCR5 dan CXCR4)--> masuk sel host--> reverse transkripsi--> integrates to cells venome