Theiler's Disease theilers-disease

Clinical signs

Fever

Ataxia

Diarrhea

Icteric

Weight loss

Photosensitisation

Anorexia

Respiratory distress

Lethargy

Clotting abnormalities

Neurologic signs

Central blindness

Aggression

Post-mortem findings

Diagnosis

Differential diagnosis

Prevention

Treatment - not specific

Icterus

Ascites

Pale and enlarged liver liver

Bile duct proliferation

Mottled and bile-stained liver

History

Clinical signs

Complete blood count (CBC) and chemistry panel

Ultrasonographic examination

Pyrrolizidine toxicosis

Hepatotoxins

Acute infectious hepatitis

Acute mycotoxicosis

Cerebral disease

Hemolytic disease.

Fluid therapy (IV crystalloid fluids with glucose and potassium)

Minimize stress

Administer B vitamins intravenously slowly and vitamin E orally

Pentoxifylline 10 mg/kg PO or IV

Nontoxic bactericidal antibiotic

Mannitol, 0.5 to 1.0 g/kg,

4 to 8 mg/kg neomycin sulfate orally q8h mixed in molasses

Restricted TAT to situations necessitating tetanus prophylaxis

Routine administration of TAT to parturient mares is strongly discouraged

Liver biopsy

Any equine biological products must be screened for any possible diseases

Epidemiology

Outcomes

Acute hepatitis

Liver failure

Other names

Acute hepatitis necrosis

Idiopathic acute hepatitis disease ( IAHD)

Postvaccinal hepatitis

Serum-associated hepatitis

Serum sickness

Etiology

Equine parvovirus-hepatitis (EqPV-H)

After receiving an equine origin biologic agent

come into contact with a horse that has received TAT

‘Theiler’s disease-associated virus’ (TDAV); Genus: Pegivirus

Colic signs

References

Conditions of the liver, spleen and pancreas. (2014). Knottenbelt and Pascoe’s Color Atlas of Diseases and Disorders of the Horse, 84–104. doi:10.1016/b978-0-7234-3660-7.00002-x

Sturgeon, B. (2017). Theiler’s disease. Veterinary Record, 180(1), 14–15. doi:10.1136/vr.j8

Divers, T. J. (2014). Liver Failure, Anemia, and Blood Transfusion. Equine Emergencies, 268–288. doi:10.1016/b978-1-4557-0892-5.00020-9

Hepatoencephalopathy (head pressing)


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Pathophysiology

virus both circulates in the serum and has trophism for the live

administration of serum/biologic products

antigen-antibody reactions may attempt to clear the virus causing an immune-related apoptosis and necrosis of hepatocyte

clinical signs of acute hepatic failure appears after 60% of functional mass is destroyed

Other horses with TDAV infection may not have any biochemical or clinical effects from the virus and some may become healthy persistent carriers

Time course

Recovered horses do not have chronic liver disease

die of hepatic failure or gradually recover over 5-10 day

4-10 weeks after equine biologic administration

onset of liver disease 1-7 days