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ANTIMICROBIAL AGENTS, MECHANISM, shutterstock_1110398051-web, iStock…
ANTIMICROBIAL AGENTS
Good Antimicrobial Drug
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Metabolized and/ or excreted slowly
Slow in development of resistance
Good solubility
Doesn't harm normal flora
Doesn't generate hipersensitivity reaction
Inexpensive
Good selective toxicity
Selective Toxicity
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HIGH
Antibacterial agents
LOW
Antiviral agents
Antiparasitic agents
Antifungal agents
Origin
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Natural
: produced by microbes
Semi-synthetic
: use chemical structure
Synthetic
: made in laboratory
ANTIBACTERIAL AGENTS
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3.
Inhibits protein synthesis
4.
Inhibits synthesis of nucleic acid
2.
Disrupt plasma membrane
5.
Inhibits synthesis of essential metabolites
1.
Inhibits synthesis of cell wall
ANTIVIRAL AGENTS
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1.
Analogues to nucleoside and nucleotide
2.
Inhibits reverse transcriptase
3.
Inhibits protease
4.
Other mechanism
ANTIFUNGAL AGENTS
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3.
Disrupts synthesis of nucleic acid
2.
Disrupts cell membrane
4.
Inhibits hyphal growth
1.
Inhibits cell wall synthesis
Resistance
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TYPES
Intrinsic
Acquired
MECHANISM
3. Altering structure of drugs' target site
5. Producing competitive metabolites
4. Altering its metabolism pathway
1. Producing enzyme to damage drugs
2. Altering membrane permeability to drugs
