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Haematopoietic stem cell niche, 八.Adult haematopoiteic stem cell…
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十二. Where hematopoietic stem cells live - the bone marrow niche (2017.antioxidants and redox signaling)
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十七. Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation(2018.cell)
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三.Hematopoietic stem cell niche maintenance during homeostasis and regeneration(2014.Nature medicine)
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十五. Single-cell and spatial transcriptomics approaches of the bone marrow microenvironment(2019. Curr Opin Oncol)
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十三. Dissecting the spatial bone marrow microenvironment of hematopoietic stem cells(2020.co-oncology)
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十四. Imaging and spatial analysis of hematopoietic stem cell niches(2019.annals of the new York academy of science)
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四. Minireview:Complexity of hematopoietic stem cell regulation in the bone marrow microenvironment(2014.Mol Endocinol)
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六 .the bone marrow microenvironment is similarly impaired in allogenenic hematopoietic stem cell transplantatiom patients with early and late poor graft function(2015.bone marrow transplantation)
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十一. A novel model for ectopic, chronic, intravital multiphoton imaging of bone marrow vasculature and architecture in split femurs.(2015.intravital)
3.disscusion
2.The split femur gives rise to a new functional vascular network that is morphologically similar to the normal bone marrow vasculature and allows intravital imaging of angiogenic responses
3.Split femurs retain myeloid progenitor cells at a low level:a model for reactive or stressed hematopoiesis?
1.In a DSC, ectopically transplanted split femursre-vascularize and continue their development in an
age-dependent manner
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2.results
- originates largely from the femoral vasculature
- bear morphologic resemblance to the femoral vasculature
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- is associated with NG2C perivascular cells
1.Transplantation of a split femur into a dorsal skin fold chamber is followed by rapid vascularisation
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7.Myeloid progenitor cells are retained in transplanted split femurs, however, total haematopoietic activity rapidly declines after transplantation