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Closed Pyometra in Cat - Coggle Diagram

- - - - During estrus cycle, estrogen produce to stimulate cervix open and relaxed
        
        Bacteria can enter into the uterus during cervix relaxed and open
        
        When no pregnancy occur
        
        Cystic or thickened lining condition can secretes fluid that create ideal environment for bacteria growth (pyometra)
        
        Infection occur can cause endometritis
        
        Endometritis lead PGF2α cannot be produce
        
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  - - - During diestrus, nongravid uterus flaccid and contain endometrial gland secretions that as growth medium for bacteria
        
        Bacteria reach uterus via ascending infection or hematogenous spread
        
        Failure to exhibit out the bacteria from uterus after estrus
        
        Result in pyometra. Septic inflammatory condition of uterus
        
        Potential leakage purulent fluid through uterine rupture can cause septic peritonitis
        
        Common bacteria: E.coli
      - Decreases myometrial contractility
      - Stimulates endometrial gland development and activity
      - suppresses the leukocyte response to infectious stimuli in uterus
- - - - When there is impairment of kidney function due to endotoxin effect froom bacteria lead to kidney cannot excrete nitrogen lead high level BUN in bod
    - - E.coli infection
      - reflect nephrogenic diabetes inspidus secondary to exotoxin
      - Hyposthenuria: production dilute urine
      - due to endotoxin effect bacteria impairment to kidney renal tubular function
  - - - Indicates iron deficiency or bone marrow exhaustion associated with uterine inflammation and toxaemia.
    - - stress and inflammation lead to high production and release of leukocyte