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APC Gene - Coggle Diagram
APC Gene
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People with mutations in the APC gene have familial adenomatous polyposis (FAP) or attenuated FAP (AFAP).
You have an increased chance to develop multiple gastrointestinal polyps, colorectal cancer, and possibly other cancers.
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The first Article was Gut micro biome associated with APC gene mutation in patients with intestinal adenomatous polyps
The entire exon region of the APC gene was sequenced in 35 patients with pathologically diagnosed adenomatous polyps.
Patients with highly pathogenic APC mutation were classified as the case group, while the others were classified as the control group.
The significantly low abundance of the Photosynthesis pathway in patients with APC mutation was due to the low abundance of species.
Host's APC mutation was closely related to the changes of gut microbiota and serum metabolites, and some species of gut micro biome.
In most cases of colorectal cancer, the DNA mutations that lead to cancer are acquired during a person's life rather than having been inherited. ... In many cases, the first mutation occurs in the APC gene.
This leads to an increased growth of colorectal cells because of the loss of this “brake” on cell growth. Further mutations may then occur in other genes, which can lead the cells to grow and spread uncontrollably. Other genes that aren’t known yet are probably involved as well.
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The Second Article is Autocatalytic Tissue Polymerization Reaction Mechanism in Colorectal Cancer Development and Growth
Classic FAP patients develop 100s to 1000s of premalignant adenomas which further supports the idea that APC mutations drive tumor growth in vivo.
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