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Liver cirrhosis - Coggle Diagram
Liver cirrhosis
Causes
Lipids is easily converted into glycerol witch is a component of fatty acids hence they accumulate in the liver
Tumours that are mestastatic
Hereditary disorders like glucosmia that alter liver function
Toxins like
Alcohol produces a state which is use instead of glucose as an energy source
the build up of glucose activate liposynthesis and hence we see a build up lipids
Drugs
Metabolic hepotoxicity
Viral infection like hepatitis abcdefg
Intra hepatic and extra hepatic biliary obstruction
Liver cirrhosis is diffuse and irreversible
it’s a fibrosis of liver tissue
Triggger
Necrosis of tissue which causes precise tissues fibrosis
this is mediated by tumour N factor
These cytokines activate cellls to produce collegen
Cytokines inhibit the activation of methaloptoteases which break down collegen which further contributes to liver cirrhosis
The fibers disposition in the space of disse Increases the width between membrane between endothelial cells and hepaticytes which means bloodthat passes through space can not be detoxified causing portal systemic shunts
Micro modular Liver cirrhosis
Macro modular liver cirrhosis
Functional presentations of of liver faluire
Jusdance
2.4-21micromoles
we see it after levels of bilirubin exceeds 34
Types
Hepatic or parenchyma
An increase in conjugated bilirubin can be due to hypoenegetic states which prevent. Bilirubin to be transported. Out of hepatocyted
Hypoenegetic states are seen in alcohol abuse
viral hepatitis ,liver toxins and shock which cause hypoxia through disrupting liver metabolism
Prehrpatic
Hemolytic anemia’s -too many unconjugated bilirubin
Hypoalbunimic states
no carrier for bilirubin
Intravascular and extravascular
Post hepatic
We see redial colour
Intra hepatic
Obstruction in the bile cancliculi
Extra hepatic occlusion
bile stones
tumours on the head of pancreases which obstructs the ductus
inflammation of bile tract
Portal hypertension
All the blood from portal vein gets dumped into liver and then enters venacava vein via hepatic vein
Portal hypertension can be due
Post hepatic
Seen in increased lymphatic nodes or book carries syndrome
preliver
Occlusion via thrombus or tumour
Ligatures and adhesions
Liver
Presinisudal
around hepatic triad
Cholenxitis
lymphoma m
Sinoudial
Sinsoudal
Fibrotic tissue that is produced in space of dissent compresses endothelial cells and fills space
Seen in steatosis/Edema in. Heptocytes which compress the sinsouuds
Post sinisoiudsl
Viral hepatitis and liver cirrhosis
allkahol byline
Complications of portal hypertension
Blood can not pass through liver and can not go through to the systematic circulation
So we see shunts occurring or : blood from GIT ENters CIRCULation via cava veins
Via venous plexus which Are very diialated. And are prone to hemorrhage
Through esaohogeal veins. We see esaphogeal varracies
So through iliac veins to the lower veins causing hemstiouds around rectum
So through umbelical veins To the uppper and lower cava. Veins
we seee Cappaa medusa.
So blood is forced through other routes to try to reach the right atrium