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ANTIPSIKOTIK - Coggle Diagram
ANTIPSIKOTIK
Skizofrenia
Gejala
Positif
Dopamin yang banyak pada jalur Mesolimbic
Halusinasi
Delusi
Thought of disorder
Bizare behavior
Negatif
Defisiensi dopamin
Poverty of speech
Restriction of amount of spontaneous speech
Flattering of affect (Loss of normal expression of emotion)
Social withdrawal
Apatis
Attention deficit
Patogenesis
Neurotransmitter alteration in mesolimbic & mesocortical areat
Neurotransmitter yg meningkat --> dopamine, 5 HT (Serotonin), NE (Norepineprin), Glutamate
Tradisional Antipsikotik/neuroleptic
memblok D2 dopamin reseptor & Alleviete the positive symptoms
Punya efek yang sedikit thdp gejala negatif / disfungsi kognitif
Agen baru --> alleviate positive & negative symptoms & improve kognitif
Poorly tolerated due to unfavorable side effect profiles
Extra pyramidal symptoms (EPS)
Tarditive Dyskinesia (TD)
Muscarinics (M1)
Histminergic (H1)
Adrenergic (A1&2)