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Pathological bleeding increases tendency towards bleeding - Coggle…
Pathological bleeding
increases tendency towards bleeding
Problems with vessels
Shelion Enoch vasculities
an infection(uri) occurres and igA antibodies antigen complex’s circulate and depositi on capillary wall and cause activation of complement and with it the cappiliry is destroyed,
we see symptoms all over the body as cappiliries are everywhere
Types (it’s hypersensitivity 3)
Type1or purpura effecting skin
found on lower limbs
The hemorages are raised and can be felt
Type 2 is Purpura that effects the movemets of joints and causes pain
Type 3 effects kidneys and causes blood in urine
Type 4 is seen in the gi
ws see malleana andhemptoais
Type 5 fuliminant purpura
combination. of all ltypes
fatall
Senile purpura
Cushing disease
Marfans syndrome
Els.downls
Scurvy
Platelate defects
Decrease in platelet count
Impaired production
fibrosis in bone marrow
leukaemia
aplastic anemia
liver damage causes decrease in thrombopotein
Increased Sequestration or isolation or trapping in spleen
occurs in splemomegaly /hyperspenisim
Increase in destruction
Seen in idiopathic thrombocytopenia
seen after URI
body produces antibodies against cell glycoproteins of thrombocytes and cause destruction via opsonisation
Acute (kids)and chronic (older)
Bleeding is spontaneous and we see parachie echimosis and effects mucus membranes and skin
might effect gi tract
Decrease in platelet function
Problem with adhesion of platelets to sub endothelium
Von willbrann facto or receptor deffincey
Problem with impaired aggregation
Seen in glandmans disease (fibrinogen receptor deficiency )
Seen in hypofibrinogemia
Inhibition of degranulatuon
Aspirin blocks cox irreversibly
causing inability to activate hemostasis
Coagulation defects
Vitamin k deficiency
usuallly activates clotting factors
so without it inactivatied factors (7,2,9,10) which are dependant in vit k circulate the blood
Vit k is produced by the bacteria in the colon so use of antibiotics and dhiiriha can cause death of bacteria
Vit k also acts in the liver and activated factors so liver failure
Deficiency of Von wilder brand factor
HaemophiliaA
x linked ressesive diseases
Haemophilia can be asymptomatic ,mild ,medium or severe (less than 2and can present broth
Haemophilia presents with late bleeding after trauma
bleding seen as henstomas and effect organs (brain and pharanyx
can even see blood in joints or hemoarthritis which causes asypetic inflammation and ankalosis(decrease in function )
Usually seen in men but also seen in women that have turners syndrome
Hemophilia c is autosomal ressecive
noth make snd female effected equally
deffeincy in factor 11
Hemphilia type b
x linked