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thrombotic diathesis - Coggle Diagram
thrombotic diathesis
Pathological Thrombotic formation
Endothelial damage
Decrease in anti thrombotic substances
Decrease in No and prostacyclin which are anti thrombotic and decrease platelate aggregation
Decrease production of thrombomodulin which ibinds to thrombin and inhibits
Increase in pro thrombotic substances
Conditions THAT CAN CAUSE E.dysfunction
trauma cancer
diabetes
MI
SEPSIS
MYOCARDITIS
HOMOCYSTENURIA
BURNS
SMOKING
Abnormal blood flow
Static
Seen in (micro circulation and veins )
decreases speed of blood which insures more for platelate to aggregate
seen in post operative time /standing and leukaemia (increased henatocite
Turbulent blood flow (seen in arteries )
caused by plaque or at biforcations
Hypercogulability
Congenital
Hyperactivity or production of any factors like factor 5
Protein c which inhibits factor 5 and protein s Is a co factor for protein c
Decreased activation of fibrolytic system
Plasminogen activator decreased and plasminogen inhibitor increased
Aquired
Paranneoplastic syndrome
lung carcinoma produces substances that activate coagulation
Trauma
burns
surgical trauma which activated endothelium and leads to coagulation
Pregnancy and oral contraceptive cause increase in estrogen
Visceral Obesity
adipocytes produce inhibitor of the plasminogen activator
and decrease nitric oxide action
Infection which might cause antophosoplipid syndrome
Antibodies attach on Cellular membrane on platelate Aggregation and activate it causing plug formation
Can be primary or secondary (which is caused by lupus)
Conditions
Hypertension
diabetes
hyperlipidemia