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Respiratory System - Coggle Diagram
Respiratory System
Physiology
Breathing Regulation
it is altered by chemoreceptors (PO2, H2, PCO2) >> increasing ventilation (O2 uptake, CO2 release)
PO2 is a peripheral chemoreceptor, PCO2 is a central chemoreceptor
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pressure and volume
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types: atmospheric pressure, intrapleural, intraalveolar
inspiration
decreasing of intrapulmonary pressure, air flow into lungs
expiration
increasing intrapulmonary pressure, air flow out from the lungs
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Normal Histology
Nasal
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Olfactory cells, basal cells, venstibula & concha
Larynx and trachea
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c shaped hyalin, pars cartilagnea, pars membranacea
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Bronchi & Bronchiole
c shaped islets, simple pseudo stratified, no goblet cells, clara cell, bronchioles >> neuolar duct >> alveolar sac
Asthma
epidemiology
mostly children 6-7 yo (4-11%), 13-14 yo (6-13%)
etiology is still unknown, but its triggered by risk factors
risk factors
modifiable = air pollutions, exposure to chemical, drug consumption, lack of prenatal care
non-modifiable = genetics, allergen sensitization gender, family history
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Normal Anatomy
Upper Respiratory Tract
Nares anterior >> Vestibulum Nasi >> Meatus Nasi inferior, medius,superior >> Nares Posterior >> Nasopharynx
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Biochemistry
Transporters of blood
oxygen
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protein
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Hemoglobin = main transporter of oxygen from lungs to tissue but also carry CO2 and H+ from tissues back to the lungs
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hb x cyanide = wouldn't let heme metHB (Fe3+) turn into Fe2+. metHB will bind to cyanide forming sianmetHB >> stop cell from being able to use oxygen
Carbon Dioxide
dissolve as gas (6%), 99% of remaining 94% transported via bicarbonic acid (HCO3-) coming from carbonic acid dissociation by an enzyme called carbonic anhydrase
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