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一.Multipotent mesenchymal stromal cells and innate immune system(2012…
一.Multipotent mesenchymal stromal cells and innate immune system(2012.nature/immunology)
3.MSCs and immune cells
neutrophils
mast cells
monocytes and macrophages
natural killer cells
IL-17-producing T helper cells
1.Role of MSCs in haematopoiesis
the bone marrow stem cell niche
role of bone marrow monocytes and macrophages
MSCs are key players in the niche
engraftment support
2.role of MSCs in physical barries
5.pattern-recognition receptors and MSCs
effects on survival,proliferation/differentiation
immunogenicity and immunoregulatory function
MSC licensing and antimicrobial activity
6.conclusion and future perspective
四． Lipids in the bone marrow :an evolving perspective(2020.Cell Metab)
1.the energy demands and resources of the skeletal system
2.lipids in the skeletal niche
3.lipids utilization for mitochondrial respiration
4.lipid droplets and their relationship to exogenous dietartary fats
5.obesity,type2 Diabetes,and the marrow niche
osteoprotective:additional weight,increasing of exogenous lipids
reduce bone formation:inability to property breakdown and utilize fatty acid
6.bone metabolic"competition"modulates whole-body metabolism
7.the paradox of marrow adiposity
8.cholesterol and its role in the niche
9.unresolved questions,challenges and potential opportunities
二.Mesenchymal cell contributions to the stem cell niche(2015.Cell stem Cell)
1.prospective isolation of MSCs using cell surface markers
2.prospective isolation of MSCs using genetically engineered mice
3.mesenchymal cells in the hematopoientic niche
4.mesenchymal cells in the development hematopoietic niche
5.mesenchymal cells in other adult stem cell niches
perspective
historical background
三． Mesenchymal stem cell (2014.the annunal review of cell and developmental biology )
TRACK 1:searching forward
1.origin and experimental basis of the concept
2.clonogenic cells
3.identity of the bone marrow stroma
4.ontogeny of the bone marrow stroma
5.skeletal stem cells and postnatal stem cell paradigm
6.direct identification of mesenchymal stem cells
7.niche cells
8.organizing cells
9.A General model
10.translating forward
TRACK2:translating backward
1.Mesenchymal stem cell
2.Mesenchymal stem cell and pluripotent cell paradigm
3.cultures of bone marrow stromal cells are not culture of stem cells
4.markers and differentiation in vitro have limited significance
5.expansion,heterogeneity,and standards
6.ubiquitous pericyte as ubiquitous mesenchymal stem cell
7.stem and stromal are not the same,and neither applies
8.culture connective tissue cells as immune modulators
9.a differnt kind of cell therapy
4.the complement system and MSCs