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TIAM2S & CRC - Coggle Diagram
TIAM2S & CRC
內部證據
tumor formation in TG higher, multiple sites
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totoal T rich in TG not con, CXCL13/BCA1 in circulation
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TIAM2S-serotonin-mediated chronic inflammations distinct from age-associated immune responses and contribute to tumorigenesis
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Cell：腸嗜鉻細胞介導腸腦軸對話的機制Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathway
1.to study whether TIAM2S regulates the serotonergic axis and participates in the progression of various human diseases.
- The current subproject is designed to characterize the mechanism and role of TIAM2S- mediated chronic inflammation in colon cancer tumorigenesis.
- Specific aim 1 will decipher the mechanism of TIAM2S-mediated chronic inflammation. Specific aim 2 will investigate the regulation of TIAM2S
the expression on serotonin homeostasis.
- Finally, we will address the role of TIAM2S in linking chronic inflammation and colon tumorigenesis using transgenic mice as well as clinical colon cancer specimen.