TIAM2S & CRC

內部證據

外部證據

tumor formation in TG higher, multiple sites

number in TG >con

aged-inflammation

lung liver colon

AOM fewer

survival rate down

cox2 independent

total serotonin rich in TG not control

CD8+ T cells rich in TG not in con

totoal T rich in TG not con, CXCL13/BCA1 in circulation

accumulated IL-23/IL-17A axis in TG

TIAM2S-serotonin-mediated chronic inflammations distinct from age-associated immune responses and contribute to tumorigenesis

total peripheral serotonin

Inflammatory Bowel Diseases

serotonin promote liver cancer

molecular regulation

sp1

TIAM2S expression in CRC cell line

synthesized and stored in the
enterochromaffin cells of the intestine

primarily in platelets and mast cell

https://zi.media/@yidianzixun/post/aUk7ab

Cell：腸嗜鉻細胞介導腸腦軸對話的機制Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathway

1.to study whether TIAM2S regulates the serotonergic axis and participates in the progression of various human diseases.

  1. The current subproject is designed to characterize the mechanism and role of TIAM2S- mediated chronic inflammation in colon cancer tumorigenesis.
  2. Specific aim 1 will decipher the mechanism of TIAM2S-mediated chronic inflammation. Specific aim 2 will investigate the regulation of TIAM2S
    the expression on serotonin homeostasis.
  3. Finally, we will address the role of TIAM2S in linking chronic inflammation and colon tumorigenesis using transgenic mice as well as clinical colon cancer specimen.