Please enable JavaScript.
Coggle requires JavaScript to display documents.
Cystic Fibrosis - Coggle Diagram
Cystic Fibrosis
Pathophysiology
Mutation of Gene
Chromosome 7
Cystic Fibrosis Transmembrane Conductance Regulator Gene
Deletion Mutation of Allele
Inherited and Recessive
Miscoded chloride ion channels
Impaired Electron-Transport
Reduced chloride secretion
Excessive Water Reabsorption
Epithelial Cells on Mucosal Surface
Electrolyte Imbalance and pH
hyponatremia
hypokalemia
hypochloremia
metabolic alkalosis
Clinical Manifestations
Respiratory
Airway Inflammation
High Frequency of Lung Infections
Persistant pneumonia
Hemoptysis
Lung Tissue Fibrosis
Chronic cough with thick sputum
Tachypnea
Barrel Chest
Chest Pain
Cyanosis
Reproductive
Males
Undescended testicles
Infertility
Female
Delayed second sex characteristics
Decreased fertility
Digestive
Portal Hypertension
Biliary cirrhosis
Abdominal Pain and Distention
Abnormal Stool
Growth Failure
Malabsorption Syndrome
Hair Change
Fatty Liver
Depigmentation of skin
Irritability
Edema
Anemia
Weight Loss and Muscle Waste
Constipation or Bowel Obstruction
Diabetes Mellitus
Alterations in Function
Respiratory
Think Mucus in Airway
Mucus Plugging
Impaired ciliary action
Air Trapping and Obstruction
Hyperinflation
Damaging Inflammatory Response
Lung Tissue Consolidation
Abscess Formation
Digestive
Impaired Water Absorption in Intestines
Pancreatic Insufficiency
Decreased digestion of carbs, proteins, and fats
Intestinal malabsorption
Impaired transport across biliary ductules
Increased viscosity of bile
Reproductive
Atrophy of Vas Deferens in Embryo
Congenital bilateral absence of the vas deferens
Treatment
Digestive
Enzyme Supplements
Management of Disease Complications
Multivitamins and Mineral Supplements
High Caloric Diet
Constipation Management
Stool Softeners
Laxatives
Exercise
Reproductive
IVF
Surgical Procedures
Respiratory
Avoid and Treat Respiratory Infections
Liquefy and clear mucus in airway
Inhaler for Bronchidilation
Anti-inflammatory Medication