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Huntington Disease - Coggle Diagram
Huntington Disease
Treatment method proposed
Gene therapy
medical
AVV vectors
must be placed n the CNS
Stem cell therapy
medical
capable of receiving glutamatergic and dopaminergic inputs from surrounding neruons
requires specific treatment window
manufacture
requires viral vector produced within Sf9 cell line
AMT-130
modified Cas9 method
Fetal transplant
medical
robust in terms of independence after treatment
can introduce virus and bacteria --> tumor
Business
Illegal to trade
manufacture
small scale expansion
non-ethical
symptoms
early neuronal death
psychosis
chorea
dementia
proteolysis
variable age of onset
increased by parental transmission
older than 40 = full penetrance affected
Diagnosis
psychiatric symptoms
sensory symptoms
motor symptoms
Existing Treatment
To control psychiatric disorders
surpress involuntary jerking
suppress chorea
To control movement disorder
Mood-stablizing
antipsychotic drugs
Antidepressants
Causes (genetics aspect)
short tandem repeat polymorphisms
CAG repeat in gene coding Huntington
neurotrophic factor production
expanded glutamine residues
ubiquitin tagging
toxic protein aggregation
early cell death
blocked axonal transport