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Breast Cancer - Coggle Diagram
Breast Cancer
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Staging
Stage 2 - growth confined to breast, mobile, lymph nodes in ipsilateral axilla
Stage 3 - tumour fixed to muscle (but not chest wall), ipsilateral lymph nodes matted and may be fixed , skin involvement is larger than tumour
Stage 1 - confined to breast, mobile
Stage 4 - complete fixation of tumour to chest wall, distant metastases
CXR, MRI, CT, liver ultrasound, bone scan, liver function tests and Ca2+ for staging
TMN staging
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- N1 - mobile ipsilateral nodes
- N2 - fixed nodes
- T1 - < 2cm
- T2 - 2-5 cm
- T3 > 5cm
-T4 - fixed to chest wall
Diagnosis
Consider metastatic disease - weight loss, breathlessness, back pain or abdominal mass
Check oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor 2 (HER2) status since this will affect treatment options
Ask direct questions - past lumps, FHx, pain, nipple discharge, skin change, change is size linked to menstrual cycle
Expression of HER2 is an adverse factor for small, otherwise good-prognosis tumours - since tumour is more likely to grow and divide
Triple assessment
Radiology
- Ultrasound for < 35 yrs
- Mammography (breast x-ray) and ultrasound for > 35 yrs
Histology & cytology
Fine needle aspiration
- If there is a cystic lump:
- Clear fluid found - discard fluid and reassure
- Bloody fluid found - send for cytology
Ultrasound guided core biopsy
- If there is a residual mass or solid lump
- If malignant - plan treatment
- If clear fluid found - discard fluid and reassure
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Key Facts
The majority of breast cancer arise from either:
- The epithelial lining of ducts and are called ductal
- From epithelium of the terminal ducts of the lobules and are called lobular
UK screening - every 3 yrs, mammography, 50-70yrs
Breast cancer is by far the MOST COMMON CANCER in women and the second most common cause of death in the UK
Familial breast cancer
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Both BRCA1 (higher risk) and BRCA2 are tumour suppression genes that act as inhibitors of cellular growth
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Around 5-10% of breast cancers are due to mutation in BRCA1 (chromosome 17) or BRCA2 (chromosome 13)
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Clinical Presentation
Most women with symptomatic rather than screen-detected breast cancer present with painless, increasing mass that may also be associated with:
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