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pathogenesis of dka, Tissue glucose uptake decrease, Glycogenolysis…
pathogenesis of dka
Tissue glucose uptake decrease
Hyperglycemia, glycosuria
Plasma osmolality increase
Thirst increase
Osmotic diuresis
Loss of water, Na+ and K+
Hypovolemia
Circulation failure, tissue perfusion decrease
Coma/death
Serum lactate increase
Glycogenolysis increase
Proteolysis increase
Decrease protein, weight loss
Gluconeogenesis increase
Lipolysis increase
Increase plasma free fatty acid
Increase ketogenesis, ketonemia,ketonuria
Anion gap metabolic acidosis
Hyperventilation/Kussmaul respiration
Vomiting