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Goodpasture's Syndrome - Coggle Diagram
Goodpasture's Syndrome
The co-existence of acute glomerulonephritis and pulmonary alveolar haemorrhage and the presence of circulating antibodies directed against an intrinsic antigen to the basement membrane of both kidney and lung
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Pathophysiology
Specific autoimmune disease caused by a type II antigen-antibody reaction leading to diffuse pulmonary haemorrhage, glomerulonephritis (and often AKI and CKD)
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Clinical Presentation
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Typically starts with symptoms of upper respiratory tract infection e.g. sneezing, nasal discharge, nasal congestion, runny nose and fever
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Differential Diagnosis
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Idiopathic pulmonary haemosiderosis - clinically similar to Goodpasture's but no anti-basement antibodies and kidneys less involved. Seen in children under 7 and associated with cow's milk.
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Treatment
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Vigorous immunosuppressive treatment
- Corticosteroids e.g. prednisolone
- Plasmapheresis (where you remove blood and clean to remove offending antibodies before inserting it back)