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Wound Healing and Scarring - Coggle Diagram
Wound Healing and Scarring
regeneration
scar
angiogenesis
`new vesels grow from venules
VEGF A
fgfs
fibroblast activation
type 3 collagen
only type 1 later
fibronectin
TGF beta
collagen production
anti inflam
PDGF
granulation tissue
scar maturation
remodeling
modify connective tissue
metalloproteinase
zinc
zinc def = poor wound healing
lysyl oxidase
cu def
replace collagen type 3 with collagen type 1
6-12 months
strength of scar grows
GFs
wound healing
first intention
small amount of tissue lost
epithelia regeneration
24 hours: clot formation, neutrophil invasion
3-7 day: angiogenesis, fibroblast inflitration
weeks: remodeling
second intention
more scarring and granulation
keloids
raised scar
extend beyond borders of wound
darker skin
type 1 and 3 collagen
tx with corticosteroid, 5-FU
hypertrophic scar
remain in borders
4 weeks after injurt
type 3 collagen
infection
pus
alter healing process
labile tissue
continuously dividing
stable tissue
permanent tissue
scar when dagmaged
stem cells
self renewal
asymmetric division
embryonic stem cell
adult stem cells
more differentead
homeiostasis