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inflammation - Coggle Diagram
inflammation
cardinal signs
rubor (redness)
vasodilation
histamine
prostaglandins
bradykinin
linked to factor 12
degraded by ACE and C1 inhibitor
calor (warmth)
tumor (swelling)
inc vascular permability
post capillary venules
changes in oncotic pressure
transudate
exudate
edema
dolor (pain)
PGE2
fever
pyrogens
inc COX
leukocytosis
infection
left shift
loss of function
acute phsee reactant
crp
ESR inc
saa
ferritin
hepcidin
fibrinogen
granulomatous
subtype of chronic
components
epithloid macrophages
lymphocyes
giant cells
t cells 1 cd4
type 4 HS
Il2 and IFN gamma
caseating granuloma
TB
area of necrosis
acute
innate immunity
phagocytes
neutrophils
exit at post cap venule
macrophages
recognize damps and pamps
TLR
inflammasome
cytoosloic protein complex
hallmark features
inc BF
vasc perm
neutrophils
rapid onset
time line
less than 2 day": neutrophils
more than 2 days: macrophages
discription
damaged tissue
pathogens
chronic
tissue destruction and repair at swame time
cells involved
macrophages
M1
classical activation
t cell release IFN gamma to activate macrophages
destruction
M2
alternative pathway
other than IFN gamma
repair
inhib M1
mononuclear cells