Patogenesis
spore inhalation --> acute pulmonary blastomycosis (PMN infiltration, granulomas & giant cells) --> spreat hematogenous to skin, bone, urogenetalia tract
Diagnosis
spesimen (sputum, pus, urin, CSF) , broad-based budding yeast cells, culture, serolgy
Therapy
Ketoconazole, Itraconazole, Amphotericin B