Please enable JavaScript.
Coggle requires JavaScript to display documents.
CANCER DRUGS - Coggle Diagram
CANCER DRUGS
Targeted therapy
Hormonal target
estrogen
SERM
eg: tamoxifen
SERD
fulvestrant
aromatase inhibitor
eg. anastrozole
androgen
androgen biosynthesis inhibitor
abiraterone acetate
nonsteroidal antiandrogen
flutamide
MoABs
target cell surface antigen
target growth factor receptors/ ligand
EGFR inhibitor (HER1)
cetuximab
panitumumab
HER2 inhibitor & conjugate (ErbB2 or HER2/neu)
Trastuzumab
Pertuzumab
Ado-trastuzumab emtansine
Erlotinib and Gefitinib
Lapatinib
proteasome target
Bortezomib(reversible)
Carfilzomib(irreversible)
mTOR inhibitor (enzyme-angiogenesis)
eg. sirolimus
HDAC target
Romidepsin
Vorinostat
angiogenesis target (VEGF)
Bevacizumab
retinoic acid receptor target
kinase inhibitor
immune system target
DNS topoisomerase inhibitor
I
camptothecin
camptothecin analog
irinotecan
MOA: replication fork rempuh complex
topotecan (not prodrug)
MOA:prevent religation
II
podophyllotoxin derivative
epipodophyllotoxin
etoposide
teniposide
MOA: prevent re-sealing
anthracyclines
eg: doxorubicin
cardiac toxicity
give dexrazoxane
MOA: stack between base pairs
form free radical
anthracenediones derivative
mitoxantrone
safer than doxorubicin
not cell cycle specific
alkylating agent
nitrogen mustard
cyclophosphamide
ifosfamide