Amlodipine Screenshot_20200419-221306

Trade names

Norvasc

Keterzia

Indications

Treat high blood pressure

Help prevent stroke, heart attack and kidney problems

Treat chronic stable angina,

Vasospastic angina

Side effects

Dizziness

Lightheadedness

Swelling ankles/ feet

Flushing

Contraindications

Liver or kidney problems

Heart attack

Severe hypotension

Haemodynamically unstable

Shock

Hypersensitivity to dihydropyridine

With obstruction of left ventricle

Storage

Keep in original container, tightly closed

Store at a room temperature

Keep away fron heat, mm and moisture

Store suspension in the fridge, avoid freezing

Keep out of reach of children

Mechanism of action

Is a dihydropyridine calcium antagonist

Inhibits transmembrane influx of calcium ions

Into vascular smooth muscle and cardiac muscle

Binds to dihydropyridine and nondihydropyridine binding sites

Depending upon movements of intracellular calcium ions

Amlodipine is peripheral arterial vasodilator

That acts directly on vascular smooth muscle

To cause reduction in peripheral resistance

And reduction in blood pressure

Route of administration

Oral